Understanding the state of pharmacogenomic testing for thiopurine methyltransferase within a large health system

被引：5
|
作者：
Root, Adam [1 ]
Johnson, Randall [1 ]
McGee, Ann [1 ]
Lee, Hui-Jie [2 ]
Yang, Siyun [2 ]
Voora, Deepak [3 ]
机构：
[1] Duke Univ Hosp, Dept Pharm, Durham, NC 27710 USA
[2] Duke Univ, Dept Biostat & Bioinformat, Durham, NC 27705 USA
[3] Duke Univ, Duke Ctr Appl Genom & Precis Med, Sch Med, Durham, NC 27708 USA
来源：
PHARMACOGENOMICS | 2020年 / 21卷 / 06期
关键词：
adverse drug reactions; thiopurines; TPMT; IMPLEMENTATION; TPMT; AZATHIOPRINE; VARIANTS;
D O I：
10.2217/pgs-2019-0148
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Aim: To investigate the current state of TPMT testing at a single-academic medical center. Methods: Single-center, retrospective chart review for patients newly prescribed a thiopurine. Data collection and evaluation included the prevalence and timing of TPMT testing, correct dosage adjustment if applicable, and incidence of myelosuppression. Results: 121 patients (71%) received TPMT testing. Out of the tested patients, 110 (90.9%) were designated as wild-type with normal metabolism. Dosing modification was appropriate in applicable patients. In unadjusted analysis, there was a lower incidence of myelosuppression among patients who were tested versus those who were not (16.5 vs 36.7%). Conclusion: Based on the study results, TPMT testing opportunities exist for nearly 30% of patients. Testing may reduce the incidence of myelosuppression.
引用
收藏
页码：411 / 418
页数：8
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