Research progress on drugs targeting the TGF-β signaling pathway in fibrotic diseases

被引：26
|
作者：
Shi, Ning [1 ,2 ,3 ]
Wang, Zhihong [4 ]
Zhu, Hecheng [5 ]
Liu, Weidong [1 ,2 ,3 ]
Zhao, Ming [5 ]
Jiang, Xingjun [1 ]
Zhao, Jin [1 ,2 ,3 ]
Ren, Caiping [1 ,2 ,3 ]
Zhang, Yan [6 ]
Luo, Longlong [4 ]
机构：
[1] Cent South Univ, Xiangya Hosp, Sch Basic Med Sci, Canc Res Inst,Dept Neurosurg, Changsha 410008, Peoples R China
[2] Cent South Univ, Chinese Minist Educ, Key Lab Carcinogenesis, Changsha 410008, Peoples R China
[3] Cent South Univ, Key Lab Carcinogenesis & Canc Invas, Chinese Minist Educ, Changsha 410008, Peoples R China
[4] Beijing Inst Pharmacol & Toxicol, State Key Lab Toxicol & Med Countermeasures, Taiping Rd 27, Beijing 100850, Peoples R China
[5] Changsha Kexin Canc Hosp, Changsha 410205, Hunan, Peoples R China
[6] Gen Hosp Chinese PLA, Med Ctr 1, Dept Obstet & Gynecol, Beijing, Peoples R China
来源：
IMMUNOLOGIC RESEARCH | 2022年 / 70卷 / 03期
基金：
中国国家自然科学基金;
关键词：
TGF-beta; TGF-beta antibodies; TGF-beta signaling pathways; Fibrosis disease; IDIOPATHIC PULMONARY-FIBROSIS; GROWTH-FACTOR-BETA; HEPATIC STELLATE CELLS; LIVER FIBROSIS; MYOFIBROBLAST DIFFERENTIATION; CARDIAC FIBROSIS; RISING INCIDENCE; TGF-BETA-1; ACTIVATION; MECHANISMS;
D O I：
10.1007/s12026-022-09267-y
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Tissue fibrosis is a key factor leading to disability and death worldwide; however, thus far, there are no approved treatments for fibrosis. Transforming growth factor (TGF)-beta is a major pro-fibrotic cytokine, which is expected to become a target in the treatment of fibrosis; however, since TGF-beta has a wide range of biological functions involving a variety of biological processes in the body, a slight change in TGF-beta may have a systematic effect. Indiscriminate inhibition of TGF-beta can lead to adverse reactions, which can affect the efficacy of treatment. Therefore, it has become very important to explore how both the TGF-beta signaling pathway is inhibited and the safe and efficient TGF-beta small molecule inhibitors or neutralizing antibodies are designed in the treatment of fibrotic diseases. In this review, we mainly discuss the key role of the TGF-beta signaling pathway in fibrotic diseases, as well as the development of fibrotic drugs in recent years, and explore potential targets in the treatment of fibrotic diseases in order to guide subsequent drug development.
引用
收藏
页码：276 / 288
页数：13
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