BOLD signal response to cocaine varies with sexual receptivity in female rats

被引：5
|
作者：
Febo, Marcelo [1 ]
Segarra, Annabell C. [2 ]
Stolberg, Tara L.
Ferris, Craig F.
机构：
[1] Northeastern Univ, Dept Psychol, Ctr Translat NeuroImaging, Boston, MA 02115 USA
[2] Univ Puerto Rico, Dept Physiol, San Juan, PR 00936 USA
来源：
NEUROREPORT | 2011年 / 22卷 / 01期
关键词：
cocaine; female rat; functional magnetic resonance imaging; lordosis; mesolimbic; nigrostriatal; sexual motivation; sexual receptivity; CONSCIOUS RATS; ESTROGEN; AMPHETAMINE; IMMUNOREACTIVITY; RECEPTORS; BEHAVIOR; NEURONS; SYSTEM;
D O I：
10.1097/WNR.0b013e3283416f81
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Blood oxygen level dependent MRI was used to test whether cocaine-stimulated mesolimbic activity varied with sexual receptivity. Rats were randomly screened for lordotic responses and were then imaged for their responses to centrally administered cocaine. We observed that female rats expressing no lordosis showed a greater activation of mesolimbic and nigrostriatal structures than lordotic female rats. Our data suggest that the differential sensitivity to cocaine occurs not only as a result of hormonal changes of the estrous cycle, but also in association with changes in sexual receptivity. NeuroReport 22:19-22 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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页码：19 / 22
页数：4
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