Inhibition of cytochrome P450 by proadifen diminishes the excitability of brain serotonin neurons in rats

被引：11
|
作者：
Grinchii, Daniil [1 ]
Paliokha, Ruslan [1 ]
Tseilikman, Vadim [2 ]
Dremencov, Eliyahu [1 ,2 ,3 ]
机构：
[1] Slovak Acad Sci, Ctr Biosci, Inst Mol Physiol & Genet, Bratislava, Slovakia
[2] South Ural State Univ, Sch Med Biol, Chelyabinsk, Russia
[3] Slovak Acad Sci, Biomed Res Ctr, Inst Expt Endocrinol, Bratislava, Slovakia
来源：
GENERAL PHYSIOLOGY AND BIOPHYSICS | 2018年 / 37卷 / 06期
关键词：
Serotonin; Dorsal raphe nucleus; in vivo electrophysiology; Proadifen hydrochloride; Cytochrome P450; Corticosterone; LIVER; METABOLISM; ACTIVATION;
D O I：
10.4149/gpb_2018040
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The aim of this study was to investigate the effect an inhibitor of cytochrome-P450, proadifen hydrochloride (SKF525), on the excitability of serotonin neurons. Adult male Wistar rats were administered SKF525 forty-eight, twenty-four, and one hour before electrophysiological assessments. Control animals were injected saline. Rats were anesthetized with chloral hydrate and glass electrodes were stereotaxically inserted into the dorsal raphe nucleus (DRN). Serotonin neurons were identified and their firing activity was recorded. It was found that the SKF525 inhibits the excitability of 5-HT neurons. We suggest that corticosterone might play a key role in the SKF525-induced inhibition of 5-HT neurons.
引用
收藏
页码：711 / 713
页数：3
相关论文
共 50 条
  • [1] Inhibition of cytochrome P450 with proadifen alters the excitability of brain catecholamine-secreting neurons
    Paliokha, Ruslan
    Grinchii, Daniil
    Khoury, Talah
    Bervanlou, Reyhaneh Nejati
    Dremencov, Eliyahu
    GENERAL PHYSIOLOGY AND BIOPHYSICS, 2022, 41 (03) : 255 - 262
  • [2] Effect of cytochrome P450 inhibition by proadifen on the excitability of central catecholamine-secreting neurons in rats
    Paliokha, R.
    Grinchii, D.
    Khoury, T.
    Dremencov, E.
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2021, 53 : S618 - S619
  • [3] Effect of cytochrome P450 inhibition by proadifen on the excitability of monoamine-secreting neurons in the rat brain
    Paliokha, R.
    Grinchii, D.
    Khoury, T.
    Dremencov, E.
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2020, 40 : S40 - S41
  • [4] Inhibition of cytochrome P450 by buckminsterfullerene
    Gannett, Peter
    Bostick, Christopher
    Tracy, Timothy
    Dolan, Emma
    Biundo, Andrew
    Tish, Wesley
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 252
  • [5] Inhibition of cytochrome P450 by thiarubrine A
    Fowler, JL
    Quinones, K
    O'Shea, KE
    Roberts-Kirchhoff, ES
    DRUG METABOLISM REVIEWS, 2004, 36 : 148 - 148
  • [6] INHIBITION OF CYTOCHROME P450 BY NORENDOXIFEN
    Liu, J.
    Lu, W.
    Flockhart, P. J.
    Lu, D.
    Han, X.
    Cushman, M.
    Flockhart, D. A.
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2013, 93 : S57 - S57
  • [7] Inhibition of platelet serotonin uptake by cytochrome P450 inhibitors miconazole and econazole
    Helmeste, DM
    Tang, SW
    Vu, R
    LIFE SCIENCES, 1998, 62 (24) : 2203 - 2208
  • [8] Brain cytochrome P450 in the rat
    Riedl, AG
    Watts, PM
    Edwards, RJ
    Boobis, AR
    Jenner, P
    BIOCHEMICAL SOCIETY TRANSACTIONS, 1996, 24 (01) : S52 - S52
  • [9] Brain localization of cytochrome P450
    Loriot, M. A.
    Dutheil, F.
    Flinois, J. P.
    Duyckaerts, C.
    Beaune, P. H.
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2008, 18 : S196 - S197
  • [10] Cytochrome P450 in the brain;: A review
    Hedlund, E
    Gustafsson, JÅ
    Warner, M
    CURRENT DRUG METABOLISM, 2001, 2 (03) : 245 - 263
12345