Meaningful associations in the adolescent brain cognitive development study

被引：91

作者：

Dick, Anthony Steven ^{[1
,2
]}

Lopez, Daniel A. ^{[3
]}

Watts, Ashley L. ^{[4
]}

Heeringa, Steven ^{[5
]}

Reuter, Chase ^{[6
]}

Bartsch, Hauke ^{[7
]}

Fan, Chun Chieh ^{[8
]}

Kennedy, David N. ^{[9
]}

Palmer, Clare ^{[10
]}

Marshall, Andrew ^{[11
,12
]}

Haist, Frank ^{[13
]}

Hawes, Samuel ^{[1
,2
]}

Nichols, Thomas E. ^{[14
]}

Barch, Deanna M. ^{[15
,16
,17
]}

Jernigan, Terry L. ^{[9
]}

Garavan, Hugh ^{[18
]}

Grant, Steven ^{[19
]}

Pariyadath, Vani ^{[19
]}

Hoffman, Elizabeth ^{[20
]}

Neale, Michael ^{[21
]}

Stuart, Elizabeth A. ^{[22
]}

Paulus, Martin P. ^{[23
]}

Sher, Kenneth J. ^{[4
]}

Thompson, Wesley K. ^{[6
,8
]}

机构：

[1] Florida Int Univ, Dept Psychol, Miami, FL 33199 USA

[2] Florida Int Univ, Ctr Children & Families, Miami, FL 33199 USA

[3] Univ Rochester, Med Ctr, Dept Publ Hlth Sci, Div Epidemiol, 601 Elmwood Ave, Rochester, NY 14642 USA

[4] Univ Missouri, Dept Psychol, Columbia, MO 65211 USA

[5] Univ Michigan, Inst Social Res, Ann Arbor, MI 48109 USA

[6] Univ Calif San Diego, Herbert Wertheim Sch Publ Hlth & Human Longev Sci, La Jolla, CA 92093 USA

[7] Haukeland Hosp, Mohn Med Imaging & Visualizat Ctr, Dept Radiol, Bergen, Norway

[8] Univ Calif San Diego, Populat Neurosci & Genet Lab, La Jolla, CA 92093 USA

[9] Univ Massachusetts, Dept Psychiat, Med Sch, Worcester, MA 01604 USA

[10] Univ Calif San Diego, Ctr Human Dev, La Jolla, CA 92093 USA

[11] Univ Southern Calif, Childrens Hosp Los Angeles, Los Angeles, CA 90007 USA

[12] Univ Southern Calif, Dept Pediat, Los Angeles, CA 90007 USA

[13] Univ Calif San Diego, Dept Radiol, La Jolla, CA 92093 USA

[14] Univ Oxford, Li Ka Shing Ctr Hlth Informat & Discovery, Oxford Big Data Inst, Nuffield Dept Populat Hlth, Oxford, England

[15] Washington Univ, Dept Psychol & Brain Sci, St Louis, MO 63130 USA

[16] Washington Univ, Dept Psychiat, St Louis, MO 63130 USA

[17] Washington Univ, Dept Radiol, St Louis, MO 63130 USA

[18] Univ Vermont, Dept Psychiat, Burlington, VT 05405 USA

[19] US Dept HHS, Behav & Cognit Neurosci Branch, Div Neurosci & Behav, NIDA,NIH, Bethesda, MD 20892 USA

[20] US Dept HHS, NIDA, NIH, Bethesda, MD USA

[21] Virginia Commonwealth Univ, Dept Psychiat, Richmond, VA 23298 USA

[22] Johns Hopkins Univ, Dept Biostat, Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA

[23] Laureate Inst Brain Res, Tulsa, OK USA

来源：

NEUROIMAGE | 2021年 / 239卷

基金：

美国国家卫生研究院;

关键词：

Adolescent brain cognitive development study; Population neuroscience; Genetics; Hypothesis testing; Reproducibility; Covariate Adjustments; Effect Sizes; HIGH-SCHOOL YEARBOOKS; STATISTICAL CONTROL; SENSITIVITY-ANALYSIS; TESTING HYPOTHESES; CAUSAL INFERENCE; SAMPLE-SIZE; DISORDER; COMPLEX; DIVORCE; FAILURE;

D O I：

10.1016/j.neuroimage.2021.118262

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The Adolescent Brain Cognitive Development (ABCD) Study is the largest single-cohort prospective longitudinal study of neurodevelopment and children's health in the United States. A cohort of n = 11,880 children aged 9-10 years (and their parents/guardians) were recruited across 22 sites and are being followed with in-person visits on an annual basis for at least 10 years. The study approximates the US population on several key sociodemographic variables, including sex, race, ethnicity, household income, and parental education. Data collected include assessments of health, mental health, substance use, culture and environment and neurocognition, as well as geocoded exposures, structural and functional magnetic resonance imaging (MRI), and whole-genome genotyping. Here, we describe the ABCD Study aims and design, as well as issues surrounding estimation of meaningful associations using its data, including population inferences, hypothesis testing, power and precision, control of covariates, interpretation of associations, and recommended best practices for reproducible research, analytical procedures and reporting of results.

引用

页数：13

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