Synthesis and antifungal activities of ω-[4-aryl-5-(1-phenyl-5-methyl-1,2,3-triazol-4-yl)-1,2,4-triazol-3-thio]-ω-(1H-1,2,4-triazol-1-yl)acetophenones

被引：23
|
作者：
Chu, CH
Hui, XP
Zhang, Y
Zhang, ZY [1 ]
Li, ZC
Liao, RA
机构：
[1] Lanzhou Univ, Dept Chem, Natl Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
[2] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China
来源：
JOURNAL OF THE CHINESE CHEMICAL SOCIETY | 2001年 / 48卷 / 01期
关键词：
1H-1,2,4-triazole; 1,2,3-triazole; thiosemicarbazide; antifungal activity;
D O I：
10.1002/jccs.200100022
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
New 4-aryl-5-(1-phenyl-5-methyl-1,2,3-triazol-4-yl)-1,2, 4-triazol-3-thiones 3 have been synthesized by the intramolecular cyclization of 4-aryl-1-(1-phenyl-5-methyl-1,2,4-triazol-4-formyl)thiosemicarbazides 2 with an 8% NaOH solution, and then 3 reacted with omega -bromo-omega-(1H-1,2,4-triazol-1-yl)acetophenone to afford omega-[4-aryl-5-(1-phenyl-5-methyl-1,2,3-triazol-4-yl)-1,2,4-triazol-3-thio]-omega-(1H-1,2,4-triazol-1-yl)-acetophenones 4. The preliminary biological test showed that the representative compounds possess some antifungal activities.
引用
收藏
页码：121 / 125
页数：5
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