Protective effects of ethanol and polyethylene glycol on adenylate depletion during cold hypoxia in rat liver

被引：0
|
作者：
Churchill, TA
Green, CJ
Fuller, BJ
机构：
[1] UNIV LONDON,ROYAL FREE HOSP,SCH MED,DEPT SURG,LONDON NW3 2QG,ENGLAND
[2] NORTHWICK PK INST MED RES,DEPT SURG RES,HARROW,MIDDX,ENGLAND
来源：
CRYO-LETTERS | 1996年 / 17卷 / 02期
关键词：
liver preservation; energy metabolism; high energy adenylates;
D O I：
暂无
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The addition of 0.5 mg/l (11 mu M) ethanol or (0.5 X 10(-4) %) PEG-400 to the preservation solution resulted in an initial maintenance of energetics (ATP and 'energy charge' levels) over short-term hypoxia (1-2 h) in rat liver. When ethanol and PEG-400 treatments were combined, there was an overall positive synergistic effect on adenylate levels. Higher concentrations of ethanol and PEG (1.0 mg/l and 5.0 mg/l) resulted in an enhanced rate of depletion of high energy phosphates, total adenylate contents and energy charge values. The data supports the use of low levels of ethanol and PEG as cytoprotective agents in preservation solutions for liver.
引用
收藏
页码：77 / 84
页数：8
相关论文
共 50 条
  • [1] Protective effects of polyethylene glycol (20 mol/L) in phosphate-buffered sucrose for rat liver preservation
    Ahmed, I
    Ahmad, N
    Attia, MS
    Lodge, JPA
    Potts, DJ
    TRANSPLANTATION PROCEEDINGS, 2001, 33 (7-8) : 3713 - 3715
  • [2] EFFECTS OF POLYETHYLENE-GLYCOL ON RAT-LIVER ALLOGRAFT-REJECTION
    TOKUNAGA, Y
    ESQUIVEL, CO
    WICOMB, WN
    ITASAKA, H
    EGAWA, H
    COLLINS, GM
    HEPATOLOGY, 1991, 14 (04) : A288 - A288
  • [3] Protective effects of neutrophil depletion on liver and renal function during experimental sepsis
    Hoesel, LM
    Neff, TA
    Pianko, MP
    Sarma, V
    Ward, PA
    SHOCK, 2004, 21 : 67 - 67
  • [4] Effects of polyethylene glycol on stability of α-chymotrypsin in aqueous ethanol solvent
    Simon, LM
    Kotormán, M
    Szabó, A
    Garab, G
    Laczko, I
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 317 (02) : 610 - 613
  • [5] Protective effect of polyethylene glycol against prolonged cold ischemia and reperfusion injury: Study in the isolated perfused rat kidney
    Hauet, T
    Mothes, D
    Goujon, JM
    Carretier, M
    Eugene, M
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2001, 297 (03): : 946 - 952
  • [6] Protective Role of Polyethylene Glycol Towards the Damaging Effects of Cadmium
    Amist, Nimisha
    Khare, Shubhra
    Azim, Zeba
    Singh, Narsingh Bahadur
    APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 2025, 197 (01) : 113 - 136
  • [7] CHANGES IN RAT STRIATUM CATECHOLAMINE DURING HYPOXIA WITH REFERENCE TO PROTECTIVE EFFECTS OF FLUNARIZINE
    YAMAZAKI, M
    MASUDA, T
    ITO, Y
    KUZE, S
    MOMOSE, Y
    PHARMACOLOGY & TOXICOLOGY, 1992, 70 (04): : 294 - 298
  • [8] Protective effects of gangliosides on cerebral neuronal damage of rat during acute hypoxia
    Xie, Yinzhi
    Zhang, Bo
    Yang, Ximing
    Yin, Zhaoyun
    Bai, Jingwen
    Yang, Haixian
    Hangtian Yixue Yu Yixue Gongcheng/Space Medicine and Medical Engineering, 2000, 13 (03): : 191 - 195
  • [9] Effects of ciprofloxacin on fetal rat liver during pregnancy and protective effects of quercetin
    Dogan, Z.
    Elbe, H.
    Taslidere, E.
    Soysal, H.
    Cetin, A.
    Demirtas, S.
    BIOTECHNIC & HISTOCHEMISTRY, 2017, 92 (07) : 481 - 486
  • [10] GLYCOGEN DEPLETION DURING COLD ISCHEMIC LIVER PRESERVATION
    JIANG, H
    CHEETHAM, K
    CHURCHILL, T
    ROLLES, K
    FULLER, B
    CRYOLETTERS, 1994, 15 (05) : 309 - 314
12345