In-vitro activity of sanfetrinem against isolates of Streptococcus pneumoniae and Staphylococcus aureus

The activity of sanfetrinem (previously GV104326), was assessed against 168 isolates of Streptococcus pneumoniae and 90 isolates of Staphylococcus aureus. These isolates included a range of serotypes or phage types, and varied in their susceptibility to other antibiotics. Sanfetrinem exhibited good anti-pneumococcal activity, with MIC(90)s of less than or equal to 0.007 mg/L and 0.5 mg/L for penicillin-susceptible and penicillin-resistant isolates, respectively. Sanfetrinem was also active against methicillin-susceptible staphylococci (MIC90 = 0.06 mg/L). However, the MICs of sanfetrinem for isolates with methicillin MICs of 8-16 mg/L and greater than or equal to 32 mg/L were 0.25-1 mg/L and 8-->32 mg/L, respectively.