CAR.CD123-NK Cells Have an Equally Effective but Safer Off-Tumor/on-Target Profile As Compared to CARCD123-T Cells for the Treatment of Acute Myeloid Leukaemia

被引：0

作者：

Caruso, Simona ^{[1
]}

Quintarelli, Concetta ^{[2
,3
]}

De Angelis, Biagio ^{[1
]}

Del Bufalo, Francesca ^{[4
]}

Ciccone, Roselia ^{[5
]}

Donsante, Samantha ^{[6
]}

Volpe, Gabriele ^{[7
]}

Manni, Simona ^{[8
]}

Guercio, Marika ^{[1
]}

Pezzella, Michele ^{[5
]}

Iaffaldano, Laura ^{[5
]}

Silvestris, Domenico Alessandro ^{[5
]}

Sinibaldi, Matilde ^{[9
]}

Di Cecca, Stefano ^{[9
]}

Pitisci, Angela ^{[4
]}

Velardi, Enrico ^{[4
]}

Merli, Pietro ^{[10
]}

Algeri, Mattia ^{[4
]}

Lodi, Mariachiara ^{[5
]}

Paganelli, Valeria ^{[5
]}

Serafini, Marta ^{[11
]}

Riminucci, Mara ^{[12
]}

Locatelli, Franco ^{[4
,13
]}

机构：

[1] IRCCS Bambino Gesu Childrens Hosp, Dept Hematol Oncol & Cell & Gene Therapy, Rome, Italy

[2] Bambino Gesu Pediat Hosp, Dept Oncohaematol & Cell & Gene Therapy, Rome, Italy

[3] Federico II Univ Naples, Dept Clin Med & Surg, Naples, Italy

[4] IRCCS Bambino Gesu Childrens Hosp, Dept Pediat Hematol Oncol Cell & Gene Therapy, Rome, Italy

[5] Bambino Gesu Pediat Hosp, Dept Oncol Haematol Cell & Gene Therapy, Rome, Italy

[6] Sapienza Univ Rome, Dept Mol Med, Rome, Italy

[7] IRCCS Bambino Gesu Childrens Hosp, Res Labs, Rome, Italy

[8] Bambino Gesu Children Hosp, Dept Oncol Haematol Cell & Gene Therapy, Rome, Italy

[9] Bambino Gesu Pediat Hosp, Dept Hematol Oncol Cell & Gene Therapy, Rome, Italy

[10] IRRCS Osped Pediat Bambino Gesu, Dept Pediat Hematol Oncol Cell & Gene Therapy, Rome, Italy

[11] M Tettamanti Res Inst, Monza, Italy

[12] Sapienza Univ Rome, Rome, Italy

[13] Univ Cattolica Sacro Cuore, Rome, Italy

来源：

BLOOD | 2022年 / 140卷

关键词：

D O I：

10.1182/blood-2022-166107

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：7369 / 7370

页数：2

共 13 条

[1] Safe and effective off-the-shelf immunotherapy based on CAR.CD123-NK cells for the treatment of acute myeloid leukaemia
Caruso, Simona
De Angelis, Biagio
Del Bufalo, Francesca
Ciccone, Roselia
Donsante, Samantha
Volpe, Gabriele
Manni, Simona
Guercio, Marika
Pezzella, Michele
Iaffaldano, Laura
Silvestris, Domenico Alessandro
Sinibaldi, Matilde
Di Cecca, Stefano
Pitisci, Angela
Velardi, Enrico
Merli, Pietro
Algeri, Mattia
Lodi, Mariachiara
Paganelli, Valeria
Serafini, Marta
Riminucci, Mara
Locatelli, Franco
Quintarelli, Concetta
JOURNAL OF HEMATOLOGY & ONCOLOGY, 2022, 15 (01)
[2] Safe and effective off-the-shelf immunotherapy based on CAR.CD123-NK cells for the treatment of acute myeloid leukaemia
Simona Caruso
Biagio De Angelis
Francesca Del Bufalo
Roselia Ciccone
Samantha Donsante
Gabriele Volpe
Simona Manni
Marika Guercio
Michele Pezzella
Laura Iaffaldano
Domenico Alessandro Silvestris
Matilde Sinibaldi
Stefano Di Cecca
Angela Pitisci
Enrico Velardi
Pietro Merli
Mattia Algeri
Mariachiara Lodi
Valeria Paganelli
Marta Serafini
Mara Riminucci
Franco Locatelli
Concetta Quintarelli
Journal of Hematology & Oncology, 15
[3] Engineered CAR.CD123 NK Cells As An Innovative "Off The Shelf" Strategy To Treat CD123POS Childhood Acute Myeloid Leukaemia
Caruso, Simona
Ciccone, Roselia
Abbaszadeh, Zeinab
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Cembrola, Biancamaria
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Camera, Antonio
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Pira, Giuseppina Li
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BONE MARROW TRANSPLANTATION, 2021, 56 (SUPPL 1) : 45 - 45
[4] CD133-directed CAR T-cells for MLL leukemia: on-target, off-tumor myeloablative toxicity
Clara Bueno
Talia Velasco-Hernandez
Francisco Gutiérrez-Agüera
Samanta Romina Zanetti
Matteo L. Baroni
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Oscar Molina
Adria Closa
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Leukemia, 2019, 33 : 2090 - 2125
[5] CD133-directed CAR T-cells for MLL leukemia: on-target, off-tumor myeloablative toxicity
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LEUKEMIA, 2019, 33 (08) : 2090 - 2093
[6] Improved Activity against Acute Myeloid Leukemia with Chimeric Antigen Receptor (CAR)-NK-92 Cells Designed to Target CD123
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VIRUSES-BASEL, 2021, 13 (07):
[7] Systematic single amino acid affinity tuning of CD229 CAR T cells retains efficacy against multiple myeloma and eliminates on-target off-tumor toxicity
Vander Mause, Erica R.
Baker, Jillian M.
Dietze, Kenneth A.
Radhakrishnan, Sabarinath V.
Iraguha, Thierry
Omili, Destiny
Davis, Patricia
Chidester, Sadie L.
Modzelewska, Katarzyna
Panse, Jens
Marvin, James E.
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Steinbach, Mary
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Lim, Carol S.
Atanackovic, Djordje
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SCIENCE TRANSLATIONAL MEDICINE, 2023, 15 (705)
[8] TCRab Deficient CAR T-Cells Targeting CD123: An Allogeneic Approach of Adoptive Immunotherapy for the Treatment of Acute Myeloid Leukemia (AML)
Galetto, Roman
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Nicole, Cruz M.
Roboz, Gail J.
Guzman, Monica L.
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BLOOD, 2015, 126 (23)
[9] Tandem bispecific CD123/CLL-1 CAR-T cells exhibit specific cytolytic effector functions against human acute myeloid leukaemia
Wang, Xiang-Yu
Bian, Mei-Ru
Lin, Guo-Qiang
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EUROPEAN JOURNAL OF HAEMATOLOGY, 2024, 112 (01) : 83 - 93
[10] Design and Production An Effective Bispecific Tandem Chimeric Antigen Receptor on T Cells against CD123 and Folate Receptor β towards B-Acute Myeloid Leukaemia Blasts
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