Aminoheterocycles as synthons for combinatorial Biginelli reactions

被引：39
|
作者：
Ryabukhin, Sergey V. [1 ,2 ]
Plaskon, Andrey S. [1 ,2 ]
Boron, Sergey Yu [1 ]
Volochnyuk, Dmitriy M. [1 ,3 ]
Tolmachev, Andrey A. [2 ]
机构：
[1] Enamine Ltd, UA-01103 Kiev, Ukraine
[2] Natl Taras Shevchenko Univ, UA-01033 Kiev, Ukraine
[3] Natl Acad Sci Ukraine, Inst Organ Chem, UA-02094 Kiev, Ukraine
来源：
MOLECULAR DIVERSITY | 2011年 / 15卷 / 01期
关键词：
Aminoheterocycles; Dihydropyrimidines; Chlorotrimethylsilane; Biginelli reaction; Multicomponent reaction; MCR; Combinatorial; Library; CHLOROTRIMETHYLSILANE; DERIVATIVES; ALDEHYDES;
D O I：
10.1007/s11030-010-9253-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Chlorotrimethylsilane (TMSCl) has been utilized as an efficient promoter and water scavenger in the synthesis of diverse dihydropyrimidines via Biginelli type MCR-heterocyclization using aminoheterocycles. High yields and a simple workup of target compounds enable the facile generation of combinatorial libraries comprising more than 2,000 compounds of high structural and functional diversity. A representative set of 89 compounds is described.
引用
收藏
页码：189 / 195
页数：7
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