Convergent synthesis of a helical, prehairpin HR1 trimer from HIV gp41

被引：1

作者：

Lu, Rong Jian ^{[1
]}

Mader, Catherine J. ^{[1
]}

Schneider, Stephen E. ^{[1
]}

Tvermoes, Nicolai ^{[1
]}

Kang, Myung-Choi ^{[1
]}

Dwyer, John J. ^{[1
]}

Wilson, Karen L. ^{[1
]}

Matthews, Thomas J. ^{[1
]}

Delmedico, Mary K. ^{[1
]}

Bray, Brian ^{[1
]}

机构：

[1] Trimeris Inc, Morrisville, NC 27560 USA

来源：

JOURNAL OF PEPTIDE SCIENCE | 2010年 / 16卷 / 09期

关键词：

convergent synthesis; protein synthesis; peptides; prehairpin gp41 HR1 trimer; oligomer; VIRUS TYPE-1 GP41; AMINO-ACID FLUORIDES; DE-NOVO DESIGN; COILED-COIL; POTENT INHIBITORS; PEPTIDE-SYNTHESIS; ENTRY; BUNDLE; BINDING; CONFORMATION;

D O I：

10.1002/psc.1262

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A helical, prehairpin trimer covering the majority of the HR1 region of human immunodeficiency virus gp41 was achieved by chemically coupling three identical 51 amino acid peptides. A 1,3,5-tris(aminomethyl)-2,4,6-triethylbenzene pinwheel 'cap' was used to trimerize the peptides by taking advantage of the unique property of triacyl fluoride and orthogonal protection and deprotection. The resulting protein is fully helical, highly thermostable and soluble. Copyright (c) 2010 European Peptide Society and John Wiley & Sons, Ltd.

引用

页码：465 / 472

页数：8

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