Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system

被引：56

作者：

Honma, Y

Kiyosawa, H

Mori, T

Oguri, A

Nikaido, T

Kanazawa, K

Tojo, M

Takeda, J

Tanno, Y

Yokoya, S

Kawabata, I

Ikeda, H

Wanaka, A

机构：

[1] Fukushima Med Univ, Sch Med, Inst Biomed Sci, Dept Cell Sci, Fukushima 9601295, Japan

[2] Asahikawa Med Coll, Dept Lab Med, Asahikawa, Hokkaido 0788307, Japan

来源：

FEBS LETTERS | 1999年 / 447卷 / 01期

关键词：

Ikaros family; molecular cloning; Zn finger; transcription factor; nervous system; development;

D O I：

10.1016/S0014-5793(99)00265-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We identified a novel member of the Ikaros gene family, which has critical roles in the development of lymphoid lineages. This gene, which we named Eos, was expressed predominantly in the developing central and peripheral nervous system. Eos protein could interact with itself and Ikaros protein through its C-terminal portion in the yeast two hybrid assay, These findings suggested that Eos may have important roles in neural development similarly to the Ikaros family in the development of hemolymphoid tissue. (C) 1999 Federation of European Biochemical Societies.

引用

页码：76 / 80

页数：5

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