Prognostication of obstructive syndrome in patients with chronic bronchitis regarding hereditary factors

Aim. To propose method of accurate prediction of chronic obstructive pulmonary disease (COPD) at early stages of development. Material and methods. 92 males with COPD and 55 males with chronic non-obstructive bronchitis aged 38 to 72 years were examined according to a technique which identifies hereditary predisposition to multifactor diseases and using an algorithm based on multivariate analysis. Results. An original mathematical model is proposed which can quantitatively examine and range by influence the role of environmental and hereditary factors in development of COPD. Conclusion. Detection of hereditary predisposition to COPD may be one of the objective criteria to recommend giving tip smoking and for occupational orientation.