Genetic Heterogeneity of Australian Candida auris Isolates: Insights From a Nonoutbreak Setting Using Whole-Genome Sequencing

被引：17

作者：

Biswas, Chayanika ^{[1
,2
]}

Wang, Qinning ^{[1
,2
]}

van Hal, Sebastiaan J. ^{[3
]}

Eyre, David W. ^{[4
]}

Hudson, Bernard ^{[5
]}

Halliday, Catriona L. ^{[2
,6
]}

Mazsewska, Krystyna ^{[6
,7
,8
]}

Gorden, Alice Kizny ^{[5
]}

Lee, Andie ^{[3
]}

Irinyi, Laszlo ^{[6
,7
,8
]}

Heath, Christopher H. ^{[9
,10
]}

Chakrabarti, Arunaloke ^{[11
]}

Govender, Nelesh P. ^{[12
,13
]}

Meyer, Wieland ^{[1
,5
,6
]}

Sintchenko, Vitali ^{[1
,2
,5
]}

Chen, Sharon C-A ^{[1
,2
,5
,6
]}

机构：

[1] Univ Sydney, Westmead Hosp, Ctr Infect Dis & Microbiol Publ Hlth, Sydney, NSW, Australia

[2] New South Wales Hlth Pathol, Inst Clin Pathol & Med Res, Ctr Infect Dis & Microbiol Lab Serv, Sydney, NSW, Australia

[3] New South Wales Hlth Pathol, Royal Prince Alfred Hosp, Dept Infect Dis & Microbiol, Sydney, NSW, Australia

[4] Univ Oxford, Big Data Inst, Oxford, England

[5] New South Wales Hlth Pathol, Dept Microbiol, Royal North Shore Hosp, Sydney, NSW, Australia

[6] Univ Sydney, Marie Bashir Inst Emerging Infect & Biosecur, Sydney, NSW, Australia

[7] Univ Sydney, Fac Med & Hlth, Ctr Infect Dis & Microbiol, Westmead Clin Sch,Mol Mycol Res Lab, Sydney, NSW, Australia

[8] Univ Sydney, Westmead Inst Med Res, Sydney, NSW, Australia

[9] PathWest Lab Med, Fiona Stanley Hosp Network, Dept Microbiol, Perth, WA, Australia

[10] Fiona Stanley Hosp, Dept Infect Dis, Perth, WA, Australia

[11] Postgrad Inst Med Educ & Res, Dept Med Microbiol, Chandigarh, India

[12] Univ Witwatersrand, Natl Inst Communicable Dis, Div Natl Hlth Lab Serv, Johannesburg, South Africa

[13] Univ Witwatersrand, Fac Hlth Sci, Johannesburg, South Africa

来源：

OPEN FORUM INFECTIOUS DISEASES | 2020年 / 7卷 / 05期

关键词：

Candida auris; drug resistance; whole-genome sequencing;

D O I：

10.1093/ofid/ofaa158

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Whole-genome sequencing clustered Australian Candida auris isolates from sporadic cases within clade III. Case isolates were genomically distinct; however, unexpectedly, those from 1 case comprised 2 groups separated by >60 single nucleotide polymorphisms (SNPs) with no isolate being identical, in contrast to outbreaks where isolates from any 1 individual have differed by <3 SNPs. Multidrug resistance was absent. High within-host genetic heterogeneity should be considered when investigating C. auris infections.

引用

页数：5

共 50 条

[1] Whole-Genome Sequencing and Phylogenetic Analysis of 43 Candida auris Isolates
Smithgall, M.
Weidmann, M.
Ofori, K.
Pang, J.
Mansukhani, M.
Wu, F.
Hsiao, S.
[J]. JOURNAL OF MOLECULAR DIAGNOSTICS, 2023, 25 (11): : S52 - S52
[2] Using Whole-Genome Sequencing to Identify Recent Introductions and Track the Spread of Candida auris in the United States
Chow, N. A.
Gade, L.
Tsay, S.
Welsh, R.
Forsberg, K.
Adams, E.
Southwick, K.
Greenko, J.
Fernandez, R.
Chiller, T.
Jackson, B.
Vallabhaneni, S.
Litvintseva, A.
[J]. MEDICAL MYCOLOGY, 2018, 56 : S156 - S156
[3] Clade distribution of Candida auris in South Africa using whole genome sequencing of clinical and environmental isolates
Naicker, Serisha D.
Maphanga, Tsidiso G.
Chow, Nancy A.
Allam, Mushal
Kwenda, Stanford
Ismail, Arshad
Govender, Nelesh P.
[J]. EMERGING MICROBES & INFECTIONS, 2021, 10 (01) : 1300 - 1308
[4] Whole-Genome Sequencing Reveals a Novel Subclade of Pansusceptible Candida auris in Ontario, Canada
Hota, Susy
Gade, Lalitha
Forsberg, Kaitlin
Susky, Erica
Poutanen, Susan
Katz, Kevin
Leis, Jerome
Nadarajah, Jeya
Amirov, Chingiz
Nankoosingh, Vydia
Williams, Victoria
Salt, Natasha
Litvintseva, Anastasia
Kus, Julianne
[J]. INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 2020, 41 : S57 - S58
[5] Using whole-genome sequencing to elucidate the epidemiology of the globally emerging, multidrug-resistant yeast Candida auris
Chow, N. A.
Gade, L.
Lockhart, S.
Vallabhaneni, S.
Caceres, D. H.
Armstrong, P.
Tsay, S.
Chaturvedi, S.
Kerins, J.
Escandon, P.
Calvo, B.
Ben-Ami, R.
Santiago, E.
Arauz, A. B.
Borace, J.
Rhodes, J. L.
Fisher, M.
Chiller, T. M.
Litvintseva, A.
[J]. MYCOSES, 2017, 60 : 21 - 21
[6] Identifying Candida auris transmission in a hospital outbreak investigation using whole-genome sequencing and SNP phylogenetic analysis
Mitchell, Brooks I.
Kling, Kendall
Bolon, Maureen K.
Rathod, Shardul N.
Malczynski, Michael
Ruiz, Javier
Polanco, Wanda
Fritz, Kevin
Maali, Sarah
Stosor, Valentina
Zembower, Teresa R.
Qi, Chao
[J]. JOURNAL OF CLINICAL MICROBIOLOGY, 2024,
[7] Whole Genome Sequencing of Australian Candida glabrata Isolates Reveals Genetic Diversity and Novel Sequence Types
Biswas, Chayanika
Marcelino, Vanessa R.
Van Hal, Sebastiaan
Halliday, Catriona
Martinez, Elena
Wang, Qinning
Kidd, Sarah
Kennedy, Karina
Marriott, Deborah
Morrissey, C. Orla
Arthur, Ian
Weeks, Kerry
Slavin, Monica A.
Sorrell, Tania C.
Sintchenko, Vitali
Meyer, Wieland
Chen, Sharon C-A
[J]. FRONTIERS IN MICROBIOLOGY, 2018, 9
[8] The use of whole-genome sequencing and development of bioinformatics to monitor overlapping outbreaks of Candida auris in southern Nevada
Gorzalski, Andrew
Ambrosio III, Frank J. J.
Massic, Lauryn
Scribner, Michelle R. R.
Siao, Danielle Denise
Hua, Chi
Dykema, Phillip
Schneider, Emily
Njoku, Chidinma
Libuit, Kevin
Sevinsky, Joel R. R.
Van Hooser, Stephanie
Pandori, Mark
Hess, David
[J]. FRONTIERS IN PUBLIC HEALTH, 2023, 11
[9] Whole genome sequencing analysis demonstrates therapy-induced echinocandin resistance in Candida auris isolates
Spruijtenburg, Bram
Ahmad, Suhail
Asadzadeh, Mohammad
Alfouzan, Wadha
Al-Obaid, Inaam
Mokaddas, Eiman
Meijer, Eelco F. J.
Meis, Jacques F.
de Groot, Theun
[J]. MYCOSES, 2023, 66 (12) : 1079 - 1086
[10] Genetic and biological insights from whole-genome sequencing of the pathogenic microalga Prototheca wickerhamii
Jagielski, T.
Bakula, Z.
Gromadka, A.
Gawor, J.
Gromadka, R.
Siedlecki, P.
[J]. MEDICAL MYCOLOGY, 2018, 56 : S6 - S6

← 1 2 3 4 5 →