RENAL DYSFUNCTION IN DENGUE VIRUS INFECTION

Dengue virus infection can exhibit a wide spectrum of renal dysfunction including tubular dysfunction (dyskalemia, dysnatremia, and acute tubular necrosis), and less commonly glomerular injury (ie microscopic herhaturia or sub-nephrotic to nephrotic range proteinuria). Data from previous reports have shown that the incidence could be up to 80%. The pathogenesis of dengue-associated renal dysfunction is still unclear. Proposed mechanisms include two major effects: direct effect and indirect effect such as hemodynamic factor and immunologic factor. Until the present time, supportive treatment is still the only key treatment in dengue-associated renal dysfunction. This narrative review aims to discuss current evidences regarding the epidemiology, pathogenesis, and various renal manifestations in dengue virus infection.