Azathioprine in the Treatment of Autoimmune Blistering Diseases

被引：5
|
作者：
Meyer, Volker [1 ]
Beissert, Stefan [1 ]
机构：
[1] Univ Munster, Dept Dermatol, D-48149 Munster, Germany
来源：
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2012年 / 32卷 / 02期
关键词：
Azathioprine; Autoimmune blistering diseases; Pemphigus; Bullous pemphigoid; METHYLPREDNISOLONE PLUS AZATHIOPRINE; THIOPURINE S-METHYLTRANSFERASE; JUVENILE PEMPHIGUS-VULGARIS; INFLAMMATORY-BOWEL-DISEASE; FOLLOW-UP; PARANEOPLASTIC PEMPHIGUS; MYCOPHENOLATE-MOFETIL; GENETIC-POLYMORPHISM; JAPANESE PATIENTS; THERAPY;
D O I：
10.1016/j.iac.2012.04.009
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Although there are no standard guidelines for the treatment of autoimmune blistering diseases, azathioprine has shown good efficacy in acquired autoimmune blistering diseases, and is well tolerated. Side effects of azathioprine normally occur in mild variants. Severe reactions are due to reduced thiopurine S-methyltransferase (TPMT) or inosine triphosphate pyrophosphohydrolase (ITPA) activity. Therefore, screening for TPMT activity should be conducted in white patients and Africans, whereas Japanese should be screened for ITPA activity before therapy with azathioprine is started. Azathioprine is clinically meaningful for the treatment of pemphigus.
引用
收藏
页码：295 / +
页数：14
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