Apolipoprotein E Polymorphism and Behavioral and Psychological Symptoms of Dementia in Patients With Alzheimer Disease

被引：31

作者：

Chen, Cheng-Sheng ^{[1
,5
,8
]}

Ouyang, Pei ^{[1
,10
,11
]}

Yeh, Yi-Chun ^{[1
]}

Lai, Chiou-Lian ^{[2
,7
]}

Liu, Ching-Kuan ^{[2
,9
]}

Yen, Cheng-Fang ^{[1
,5
]}

Ko, Chih-Hung ^{[1
,5
]}

Yen, Ju-Yu ^{[1
,5
,8
]}

Liu, Gin-Chun ^{[3
]}

Juo, Suh-Hang Hank ^{[4
,6
]}

机构：

[1] Kaohsiung Med Univ Hosp, Dept Psychiat, Kaohsiung, Taiwan

[2] Kaohsiung Med Univ Hosp, Dept Neurol, Kaohsiung, Taiwan

[3] Kaohsiung Med Univ Hosp, Dept Med Imaging, Kaohsiung, Taiwan

[4] Kaohsiung Med Univ Hosp, Dept Med Res, Kaohsiung, Taiwan

[5] Kaohsiung Med Univ, Dept Psychiat, Kaohsiung, Taiwan

[6] Kaohsiung Med Univ, Dept Med Genet, Kaohsiung, Taiwan

[7] Kaohsiung Med Univ, Dept Neurol, Kaohsiung, Taiwan

[8] Kaohsiung Med Univ, Grad Inst Med, Coll Med, Kaohsiung, Taiwan

[9] Kaohsiung Municipal Hsiaokang Hosp, Kaohsiung, Taiwan

[10] Chang Gung Univ, Dept Occupat Therapy, Tao Yuan, Taiwan

[11] Chang Gung Univ, Grad Inst Clin Behav Sci, Coll Med, Tao Yuan, Taiwan

来源：

ALZHEIMER DISEASE & ASSOCIATED DISORDERS | 2012年 / 26卷 / 02期

关键词：

agitation; delusion; Alzheimer disease; ApoE gene; NEUROPSYCHIATRIC INVENTORY; LATE-ONSET; PSYCHOTIC SYMPTOMS; AGGRESSIVE-BEHAVIOR; EPSILON-4; ALLELE; E GENOTYPE; NONCOGNITIVE SYMPTOMS; BIOLOGICAL ASPECTS; LEWY BODIES; CORTEX;

D O I：

10.1097/WAD.0b013e31821f5787

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The aims of this study were to identify subsyndromes of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer disease (AD), and to investigate whether the apolipoprotein E (ApoE) gene confers a risk of distinct BPSD subsyndromes. BPSD of 96 patients with AD were assessed using the Neuropsychiatric Inventory. Factor analysis with principal component analysis and varimax rotation was used to construct the BPSD subsyndromes. ApoE genotypes were determined using the TaqMan technology. The results showed that the 5 subsyndromes can be determined, including: agitation/aggression-delusion, euphoria-disinhibition, depression-apathy, hallucination-nighttime behavior, and appetite. ApoE epsilon 4 carriers had higher factor scores in the agitation/aggression-delusion subsyndrome. We demonstrated that ApoE epsilon 4 confers a higher risk for the subsyndrome of agitation/aggression delusion in AD.

引用

页码：135 / 139

页数：5

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