New type of chimeric fusion product between the EWS and ATFI genes in clear cell sarcoma (malignant melanoma of soft parts)

被引：0
|
作者：
Pellin, A [1 ]
Monteagudo, C [1 ]
Lopez-Gines, C [1 ]
Carda, C [1 ]
Boix, J [1 ]
Llombart-Bosch, A [1 ]
机构：
[1] Univ Valencia, Sch Med, Dept Pathol, Valencia, Spain
来源：
GENES CHROMOSOMES & CANCER | 1998年 / 23卷 / 04期
关键词：
D O I：
10.1002/(SICI)1098-2264(199812)23:4<358::AID-GCC11>3.3.CO;2-V
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We report a new case of clear cell sarcoma (CCS) harboring the t(12;22)(q13;q12). Reverse transcription-polymerase chain reaction (RT-PCR) analysis revealed the presence of a chimeric transcript between the EWS and ATFI genes, both in primary and metastatic tissue. Sequencing studies disclosed an in-frame fusion between EWS gene codon 265 and ATFI gene codon 110. This breakpoint has not been reported previously and indicates an important in vivo loss of EWS and ATFI gene domains, which could be associated with the unusually aggressive behavior of this tumor. Genes Chromosomes Cancer 23:358-360, 1998. (C) 1998 Wiley-Liss, Inc.
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页码：358 / 360
页数：3
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