Oxytocin Receptor Gene Polymorphism in Lactating Dogs

Simple Summary: Oxytocin is commonly known for its role in mammalian bonding. Several studies have proved that polymorphisms of the oxytocin receptor gene are related to complex social behaviors in humans, but studies on the possible correlation between canine social behavior and oxytocin are mainly focused on the human-dog bond, and there are no data on the possible correlation between oxytocin receptor gene polymorphism and the maternal behavior of this species. Since mother-litter interactions could have a severe impact in determining later behavior in domestic dogs, the aim of this work was to investigate the possible correlation between salivary oxytocin, maternal care and the one known single-nucleotide polymorphism (rs8679684) located in the untranslated regulatory region of the oxytocin receptor gene in 19 lactating Labrador Retriever dogs. A significant correlation between oxytocin receptor gene polymorphism, peripheral oxytocin and maternal behavior in dogs was found. This implies that a more functional oxytocinergic system would lead to better mothering in dogs. Genetic variations in the oxytocinergic system, known to regulate social behavior throughout the evolution of mammals, are believed to account for differences in mammalian social behavior. Particularly, polymorphic variants of the oxytocin receptor (OXTR) gene have been associated with behavioral variations in both humans and dogs. In this study, we offered evidence of the correlation between levels of salivary oxytocin (sOXT), maternal behavior and a single-nucleotide gene variant in OXTR (rs8679684) in nineteen lactating Labrador Retriever dogs. Carriers of at least one copy of the minor A allele showed higher levels of sOXT and maternal care in comparison with the homozygous T allele carriers. Considering the relevance of mother care in newborn development, these findings could help us to better understand the possible impact of variants in the OXTR gene in selecting dams.