PET-ONLY 18F-AV1451 TAU QUANTIFICATION

被引：0
|
作者：
Bourgeat, P. [1 ]
Villemagne, V. L. [2 ,4 ]
Dore, V. [1 ,4 ]
Masters, C. L. [2 ]
Ames, D. [3 ]
Rowe, C. C. [4 ]
Salvado, O. [1 ]
Fripp, J. [1 ]
机构：
[1] CSIRO, Hlth & Biosecur, Canberra, ACT, Australia
[2] Mental Hlth Res Inst, Parkville, Vic, Australia
[3] Natl Ageing Res Inst, Parkville, Vic, Australia
[4] Dept Nucl Med & Ctr PET, Parkville, Vic, Australia
来源：
2017 IEEE 14TH INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING (ISBI 2017) | 2017年
基金：
美国国家卫生研究院; 加拿大健康研究院;
关键词：
D O I：
暂无
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
In vivo tau imaging with PET is a promising new modality that offers a unique insight into Alzheimer's disease (AD) pathology. F-18-AV1451 is a tau tracer currently being evaluated in both AIBL and ADNI. While MR-based quantification remains the gold standard, there is great interest in PET-only quantification techniques for use in patients who cannot undergo MRI. In this study, 3 PET-only methods (single atlas, adaptive atlas, and PCA-based atlas) are evaluated and compared to an MR-based quantification in both AIBL (94 subjects) and ADNI (87 subjects). Results show that all quantifications performed using PET-only normalization approaches did equally well, with an average quantification error around 2% in both cohorts.
引用
收藏
页码：1173 / 1176
页数：4
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