Three-component synthesis of β-aminoxy amides

被引：3
|
作者：
Zeng, Linwei [1 ]
Xu, Shuheng [2 ]
Cui, Sunliang [2 ]
Zhang, Fengzhi [1 ]
机构：
[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China
[2] Zhejiang Univ, Coll Pharmaceut Sci, Inst Drug Discovery & Design, Hangzhou 310058, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2022年 / 9卷 / 14期
基金：
中国博士后科学基金; 中国国家自然科学基金;
关键词：
N-O TURNS; MULTICOMPONENT REACTIONS; ALPHA-AMINOXY; CYCLIC HEXAPEPTIDE; PASSERINI REACTION; YNAMIDES; PEPTIDES; ACIDS; FOLDAMERS; PEPTIDOMIMETICS;
D O I：
10.1039/d2qo00631f
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A multicomponent reaction for the synthesis of beta-aminoxy amides is described. In this reaction, N-hydroxamic acids, ynamides and aldehydes could assemble efficiently to deliver structurally diverse beta-aminoxy amides under the promotion of BF3-Et2O. This protocol features readily available starting materials, high atom economy, mild reaction conditions and facile scalability. Control reactions and a crossover experiment provide insights into the process for elucidating a plausible mechanism.
引用
收藏
页码：3757 / 3762
页数：6
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