user

The Mechanism of the Negative Chronotropic and Dromotropic Actions of Adenosine 5′-triphosphate in the Heart: An Update

被引：28
|
作者：
Pelleg, Amir [1 ]
Belhassen, Bernard [2 ]
机构：
[1] Drexel Univ, Coll Med, Div Cardiol, Dept Med, Philadelphia, PA 19102 USA
[2] Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Sackler Fac Med, IL-69978 Tel Aviv, Israel
来源：
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | 2010年 / 56卷 / 01期
关键词：
PSVT; syncope; vagus; cardiac pacing; TRIGGERED VAGAL REFLEX; SINUS NODE DYSFUNCTION; SUPRAVENTRICULAR TACHYCARDIA; NONINVASIVE DIAGNOSIS; REENTRANT TACHYCARDIA; CARDIAC RECEPTORS; SENSORY ORGAN; ATP TEST; TRIPHOSPHATE; SYNCOPE;
D O I：
10.1097/FJC.0b013e3181e0f8b2
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Adenosine 5'-triphosphate (ATP) plays a critical role in intracellular metabolism and energetics. Extracellular ATP is rapidly degraded to adenosine by ectoenzymes. Both ATP and adenosine suppress cardiac pacemakers' automaticity and atrioventricular nodal conduction, albeit via the different mechanism of actions. This historical update summarizes the current knowledge regarding the negative chronotropic and dromotropic actions of ATP and discusses the clinical implications regarding the utility of ATP as a diagnostic and therapeutic agent in the management of neutrally mediated syncope and paroxysmal supra ventricular tachycardia.
引用
收藏
页码：106 / 109
页数：4
相关论文
共 50 条
  • [1] Age-related negative chronotropic and dromotropic actions of adenosine
    Manolatos, D
    Sioras, E
    Filippatos, G
    Economou, D
    Balatsouras, D
    Prosmiti, N
    Kardara, D
    Flessas, L
    Sideris, A
    Kardaras, F
    [J]. EUROPEAN HEART JOURNAL, 2000, 21 : 441 - 441
  • [2] MECHANISM OF THE NEGATIVE DROMOTROPIC EFFECT OF ADENOSINE 5'-TRIPHOSPHATE IN THE GUINEA-PIG HEART INVIVO
    XU, J
    WANG, L
    HURT, C
    PELLEG, A
    [J]. DRUG DEVELOPMENT RESEARCH, 1993, 28 (03) : 290 - 295
  • [3] MECHANISM OF THE NEGATIVE DROMOTROPIC ACTION OF ADENOSINE 5'-TRIPHOSPHATE ON AV NODAL CONDUCTION IN THE GUINEA-PIG HEART INVIVO
    XU, J
    WANG, L
    HURT, CM
    PELLEG, A
    [J]. CIRCULATION, 1992, 86 (04) : 562 - 562
  • [4] CHRONOTROPIC AND DROMOTROPIC ACTIONS OF ACETYLCHOLINE ON THE DEVELOPING FETAL HEART
    DANILO, P
    BINAH, O
    HORDOF, A
    [J]. DEVELOPMENTAL PHARMACOLOGY AND THERAPEUTICS, 1993, 20 (3-4): : 231 - 238
  • [5] A comparison of the chronotropic and dromotropic actions between adenosine triphosphate and edrophonium in patients undergoing coronary artery bypass graft surgery
    Watanabe, S
    Kono, Y
    Oishi-Tobinaga, Y
    Yamada, S
    Hara, M
    Kano, T
    [J]. JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, 2002, 16 (05) : 598 - 602
  • [6] ADENOSINE MEDIATES THE NEGATIVE CHRONOTROPIC ACTION OF ADENOSINE 5'-TRIPHOSPHATE IN THE CANINE SINUS NODE
    PELLEG, A
    MITSUOKA, T
    MICHELSON, EL
    MENDUKE, H
    [J]. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1987, 242 (03): : 791 - 795
  • [7] Neuronal nitric oxide facilitates vagal chronotropic and dromotropic actions on the heart
    Conlon, K
    Kidd, C
    [J]. JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM, 1999, 75 (2-3): : 136 - 146
  • [8] PERTUSSIS TOXINS INHIBIT THE NEGATIVE CHRONOTROPIC AND NEGATIVE DROMOTROPIC EFFECTS OF CARBACHOL ON THE HEART
    SCHMITZ, W
    BOHM, M
    BRUCKNER, R
    SCHOLZ, H
    WILKEN, A
    [J]. ZEITSCHRIFT FUR KARDIOLOGIE, 1986, 75 : 31 - 31
  • [9] Potentiation of the negative dromotropic effect of adenosine by rapid heart rates: possible ionic mechanism
    Martynyuk, AE
    Zima, A
    Seubert, CN
    Morey, TE
    Belardinelli, L
    Dennis, DM
    [J]. BASIC RESEARCH IN CARDIOLOGY, 2002, 97 (04) : 295 - 304
  • [10] Potentiation of the negative dromotropic effect of adenosine by rapid heart rates: possible ionic mechanism
    Anatoly E. Martynyuk
    Aleksey Zima
    Christoph N. Seubert
    Timothy E. Morey
    Luiz Belardinelli
    Donn M. Dennis
    [J]. Basic Research in Cardiology, 2002, 97 : 295 - 304
12345