Synthesis and antitumour activity of pyrene-linked pyrrolo [2,1-c][1,4]benzodiazepine hybrids

被引：54
|
作者：
Kamal, A [1 ]
Ramesh, G [1 ]
Srinivas, O [1 ]
Ramulu, P [1 ]
机构：
[1] Indian Inst Chem Technol, Div Organ Chem, Biotransformat Lab, Hyderabad 500007, Andhra Pradesh, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 02期
关键词：
pyrrolobenzodiazepines; pyrene amine; cytotoxity; DNA-binding affinity;
D O I：
10.1016/j.bmcl.2003.10.050
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Pyrene-linked pyrrolobenzodiazepine hybrids have been synthesized that exhibit potential anticancer activity in a number of human tumour cell lines. These hybrids also exhibit much enhanced DNA-binding ability in comparison to the parent pyrrolobenzodiazepine ring system (DC-81). (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码：471 / 474
页数：4
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