A zebrafish nanos-related gene is essential for the development of primordial germ cells

被引：7

作者：

Köprunner, M

Thisse, C

Thisse, B

Raz, E ^{[1
]}

机构：

[1] Max Planck Inst Biophys Chem, D-37077 Gottingen, Germany

[2] ULP, INSERM, CNRS, Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch Graffenstaden, CU Strasbourg, France

来源：

GENES & DEVELOPMENT | 2001年 / 15卷 / 21期

关键词：

nanos; germ line; PGC; germ plasm; maternal RNA; cell migration; zebrafish;

D O I：

暂无

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Asymmetrically distributed cytoplasmic determinants collectively termed germ plasm have been shown to play an essential role in the development of primordial germ cells (PGCs). Here, we report the identification of a nanos-like (nanos1) gene, which is expressed in the germ plasm and in the PGCs of the zebrafish. We find that several mechanisms act in concert to restrict the activity of Nanos1 to the germ cells including RNA localization and control over the stability and translatability of the RNA. Reducing the level of Nanos1 in zebrafish embryos revealed an essential role for the protein in ensuring proper migration and survival of PGCs in this vertebrate model organism.

引用

页码：2877 / 2885

页数：9

共 50 条

[1] Visualization and motility of primordial germ cells using green fluorescent protein fused to 3'UTR of common carp nanos-related gene
Kawakami, Yutaka
Saito, Taiju
Fujimoto, Takafumi
Goto-Kazeto, Rie
Takahashi, Eisuke
Adachi, Shinji
Arai, Katsutoshi
Yamaha, Etsuro
[J]. AQUACULTURE, 2011, 317 (1-4) : 245 - 250
[2] Identification and origin of the germline stem cells as revealed by the expression of nanos-related gene in planarians
Sato, Kimihiro
Shibata, Norito
Orii, Hidefumi
Amikura, Reiko
Sakurai, Takashige
Agata, Kiyokazu
Kobayashi, Satoru
Watanabe, Kenji
[J]. DEVELOPMENT GROWTH & DIFFERENTIATION, 2006, 48 (09) : 615 - 628
[3] nanos function is essential for development and regeneration of planarian germ cells
Wang, Yuying
Zayas, Ricardo M.
Guo, Tingxia
Newmark, Phillip A.
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (14) : 5901 - 5906
[4] Primordial germ cell development in zebrafish
Raz, E
[J]. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2002, 13 (06) : 489 - 495
[5] Histological differentiation of primordial germ cells in zebrafish
Nagai, T
Yamaha, E
Arai, K
[J]. ZOOLOGICAL SCIENCE, 2001, 18 (02) : 215 - 223
[6] Xenopus Nanos1 is required to prevent endoderm gene expression and apoptosis in primordial germ cells
Lai, Fangfang
Singh, Amar
King, Mary Lou
[J]. DEVELOPMENT, 2012, 139 (08): : 1476 - 1486
[7] Expression of a linker histone-like gene in the primordial germ cells in zebrafish
Müller, K
Thisse, C
Thisse, B
Raz, E
[J]. MECHANISMS OF DEVELOPMENT, 2002, 117 (1-2) : 253 - 257
[8] A vasa-like gene in zebrafish identifies putative primordial germ cells
Olsen, LC
Aasland, R
Fjose, A
[J]. MECHANISMS OF DEVELOPMENT, 1997, 66 (1-2) : 95 - 105
[9] Primordial germ-cell development: The zebrafish perspective
Raz, E
[J]. NATURE REVIEWS GENETICS, 2003, 4 (09) : 690 - 700
[10] Primordial germ-cell development: the zebrafish perspective
Erez Raz
[J]. Nature Reviews Genetics, 2003, 4 : 690 - 700

← 1 2 3 4 5 →