p38 MAP kinase activity modulates αβ T cell development

被引：0
|
作者：
Mulroy, T
Sen, J
机构：
[1] Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA
[2] Childrens Hosp, Dept Pediat, Boston, MA 02115 USA
[3] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA
来源：
EUROPEAN JOURNAL OF IMMUNOLOGY | 2001年 / 31卷 / 10期
关键词：
thymus; pre-T cell receptor; signal transduction; p38 MAP kinase;
D O I：
10.1002/1521-4141(2001010)31:10<3056::AID-IMMU3056>3.0.CO;2-B
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Reciprocal interactions between bone marrow derived precursor cells and the thymic environment lead to the generation of the complete repertoire of diverse and functional T cells. We have previously shown that p38 MAP kinase is activated in response to intrathymic signals in thymocytes. In this report we provide evidence that p38 MAP kinase activity is essential for pre-TCR-mediated transition of thymocytes; from the CD4(-) CD8(-) to the CD4(+) CD8(+) stage of development. In the absence of p38 MAP kinase activity differentiation of ap T cells, but not gamma delta T cells, was blocked.
引用
收藏
页码：3056 / 3063
页数：8
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