Clinical and Quality of Life Outcomes Following Temperature-Controlled Radiofrequency Neurolysis of the Posterior Nasal Nerve (RhinAer) for Treatment of Chronic Rhinitis

被引:15
|
作者
Lee, Jivianne T. [1 ]
Abbas, Gregory M. [2 ]
Charous, Daniel D. [3 ]
Cuevas, Mandy [4 ]
Goktas, Onder [5 ]
Loftus, Patricia A. [6 ]
Nachlas, Nathan E. [7 ]
Toskala, Elina M. [8 ]
Watkins, Jeremy P. [9 ]
Brehmer, Detlef [10 ,11 ,12 ]
机构
[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Head & Neck Surg, Los Angeles, CA 90095 USA
[2] Adv ENT & Allergy, Louisville, KY USA
[3] Arizona Desert Ear Nose & Throat Specialists, Goodyear, AZ USA
[4] Tech Univ Dresden, Univ Clin Carl Gustav Carus, Dept Otorhinolaryngol, Dresden, Germany
[5] HNO Zentrum Kudamm, ENT Ctr, Berlin, Germany
[6] Univ Calif San Francisco, Dept Otolaryngol Head & Neck Surg, San Francisco, CA USA
[7] ENT & Allergy Associates Florida, Boca Raton, FL USA
[8] Thomas Jefferson Univ, Dept Otolaryngol Head & Neck Surg, Philadelphia, PA 19107 USA
[9] Ft Worth ENT Grp, Ft Worth, TX USA
[10] Univ Witten Herdecke, Fac Med, Witten, Germany
[11] Westphalian Univ Appl Sci, Dept Elect Engn & Appl Nat Sci, Gelsenkirchen, Germany
[12] Private ENT Practice, Dept Otorhinolaryngol, Gottingen, Germany
关键词
radiofrequency; temperature-controlled; neurolysis; posterior nasal nerve; rTNSS; chronic rhinitis; quality of life; MiniRQLQ; ALLERGIC RHINITIS;
D O I
10.1177/19458924221109987
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Background Temperature-controlled radiofrequency (TCRF) neurolysis of the posterior nasal nerve (PNN; RhinAer) is a minimally invasive treatment option for patients with chronic rhinitis. Objective To determine clinical outcomes and quality of life (QoL) following TCRF neurolysis of the PNN. Methods A prospective single-arm study of 129 patients with chronic rhinitis at 16 medical centers in the United States and Germany. Results The mean 24-h reflective total nasal symptom score (rTNSS) improved from 7.8 (95% CI, 7.5-8.1) at baseline to 3.6 (95% CI, 3.2-4.0) at 3 months and continued to improve to 2.9 (95% CI, 2.5-3.3) at 6 months (p < .001 comparing follow-up to baseline and p = .002 comparing 3 and 6 months). This represents 53.8% improvement over baseline at 3 months and 62.8% improvement at 6 months. Rhinorrhea, congestion, sneezing, and itching subscores and postnasal drip and cough scores were all significantly improved over baseline at both timepoints. At 3 months, 76.2% (95% CI, 68.1%-82.8%) of patients achieved a minimal clinically important difference of >= 30% improvement in rTNSS over baseline and the percentage was higher at 6 months (83.5% [95% CI, 75.8%-89.0%]). At 3 months, 80.3% (95% CI, 72.6%-86.3%) reported a minimal clinically important difference of >= 0.4-point improvement in the mini rhinoconjunctivitis quality of life questionnaire score, and the percentage was higher at 6 months; 87.7% (95% CI, 80.7%-92.4%). There were no serious adverse events with a relationship to the device/procedure reported through 6 months. Conclusion In this large, multicenter study, TCRF neurolysis of the PNN was safe and resulted in a significant reduction in rhinitis symptom burden at 3 months that was sustained/improved through 6 months. The majority of patients reported a clinically relevant improvement in QoL at 3 and 6 months postprocedure.
引用
收藏
页码:747 / 754
页数:8
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