On the analysis of large-scale genomic structures

被引：1

作者：

Oiwa, NN ^{[1
]}

Goldman, C ^{[1
]}

机构：

[1] Univ Sao Paulo, Inst Fis, BR-05315970 Sao Paulo, SP, Brazil

来源：

CELL BIOCHEMISTRY AND BIOPHYSICS | 2005年 / 42卷 / 02期

基金：

巴西圣保罗研究基金会;

关键词：

large-scale genomic analysis; long-range correlation; generalized fractal dimension; singularity spectrum; genBank; introns; intergenes spaces;

D O I：

10.1385/CBB:42:2:145

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We apply methods from statistical physics (histograms, correlation functions, fractal dimensions, and singularity spectra) to characterize large-scale structure of the distribution of nucleotides along genomic sequences. We discuss the role of the extension of noncoding segments ("junk DNA") for the genomic organization, and the connection between the coding segment distribution and the high-eukaryotic chromatin condensation. The following sequences taken from GenBank were analyzed: complete genome of Xanthomonas campestri, complete genome of yeast, chromosome V of Caenorhabditis elegans, and human chromosome XVII around gene BRCA1. The results are compared with the random and periodic sequences and those generated by simple and generalized fractal Cantor sets.

引用

页码：145 / 165

页数：21

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