Serum levels of IL-6, IL-8, and IL-10 are indicators of prognosis in pancreatic cancer

被引：84
|
作者：
Feng, Lanyun [1 ,2 ]
Qi, Qi [1 ,2 ]
Wang, Peng [1 ,2 ]
Chen, Hao [1 ,2 ]
Chen, Zhen [1 ,2 ]
Meng, Zhiqiang [1 ,2 ]
Liu, Luming [1 ,2 ]
机构：
[1] Fudan Univ, Shanghai Canc Ctr, Dept Integrat Oncol, Shanghai, Peoples R China
[2] Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R China
来源：
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2018年 / 46卷 / 12期
基金：
中国国家自然科学基金;
关键词：
Pancreatic cancer; interleukin; IL-6; IL-8; IL-10; prediction marker; HEPATOCELLULAR-CARCINOMA; POOR-PROGNOSIS; EXPRESSION; INTERLEUKIN-8; CYTOKINES; GROWTH; CELLS; CXCL8/IL-8; ACTIVATION; IL-1-BETA;
D O I：
10.1177/0300060518800588
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Objective Early detection and prognosis prediction are critical to improve patient survival in pancreatic cancer. This study aimed to investigate whether interleukins could serve as indicators of prognosis in pancreatic cancer. Methods Sixty-eight patients with pancreatic cancer were enrolled in the study during the period between 2012 and 2014. The serum levels of a broad spectrum of interleukins in these patients were determined, including IL-1 beta, IL-2, IL-6, IL-8, IL-10, IL-13, IL-15, and IL-23. Results IL-6, IL-8, and IL-10 showed significant positive correlations with each other. Moreover, high levels of serum IL-6, IL-8, and IL-10 were independently strongly associated with poor survival of patients with pancreatic cancer. Conclusions Our results suggest that serum levels of IL-6, IL-8, and IL-10 could be useful markers for prediction of prognosis in patients with pancreatic cancer.
引用
收藏
页码：5228 / 5236
页数：9
相关论文
共 50 条
  • [1] IL-6, IL-8 and IL-10 Levels in Healthy Weight and Overweight Children
    Tam, Charmaine S.
    Garnett, Sarah P.
    Cowell, Christopher T.
    Heilbronn, Leonie K.
    Lee, Jennifer W.
    Wong, Melanie
    Baur, Louise A.
    [J]. HORMONE RESEARCH IN PAEDIATRICS, 2010, 73 (02): : 128 - 134
  • [2] Serum levels of IL-6, IL-8 and IL-10 and risks of end-stage kidney disease and mortality
    Chen, Teresa K.
    Estrella, Michelle M.
    Appel, Lawrence J.
    Coresh, Josef
    Luo, Shengyuan
    Obeid, Wassim
    Parikh, Chirag R.
    Grams, Morgan E.
    [J]. NEPHROLOGY DIALYSIS TRANSPLANTATION, 2021, 36 (03) : 561 - 563
  • [3] Prognostic values of IL-6, IL-8, and IL-10 in acute pancreatitis
    Stimac, D
    Fisic, E
    Milic, S
    Bilic-Zulle, L
    Peric, R
    [J]. JOURNAL OF CLINICAL GASTROENTEROLOGY, 2006, 40 (03) : 209 - 212
  • [4] SERUM LEVELS OF 1,3-BETA-D-GLUCAN CORRELATE WITH IL-6, IL-8 AND IL-10 IN ACLF PATIENTS WITH POOR PROGNOSIS
    Herber, Adam
    Fischer, Janett
    Aehling, Niklas
    Engelmann, Cornelius
    Veelken, Rhea
    Petros, Sirak
    Weidhase, Lorenz
    Berg, Thomas
    Van Boemmel, Florian
    [J]. HEPATOLOGY, 2022, 76 : S916 - S916
  • [5] Correlation of serum IL-6, IL-8 and IL-10 levels with clinicopathological features and prognosis in patients with diffuse large B-cell lymphoma
    Duletic, A. Nacinovic
    Stifter, S.
    Dvornik, S.
    Skunca, Z.
    Jonjic, Nives
    [J]. INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, 2008, 30 (03) : 230 - 239
  • [6] Serum IL-6, IL-8 and IL-10 levels in multiple trauma compared to traumatic brain injury and combined trauma
    Seekamp A.
    Van Griensven M.
    Lehmann U.
    Molituris U.
    Hildebrandt F.
    Pohlemann T.
    [J]. European Journal of Trauma, 2002, 28 (3): : 183 - 189
  • [7] Serum TNF-α, sTNFR1, IL-6, IL-8 and IL-10 levels in Weil's syndrome
    Kyriakidis, Ioannis
    Samara, Pinelopi
    Papa, Anna
    [J]. CYTOKINE, 2011, 54 (02) : 117 - 120
  • [8] IL-10/IL-6 serum ratio as a prognosis marker of STEMI
    Leboube, Simon
    Hayek, Ahmad
    Paccalet, Alexandre
    da Silva, Claire Crola
    Amaz, Camille
    Varillon, Yvonne
    Rioufol, Gilles
    Prieur, Cyril
    Bonnefoy-Cudraz, Eric
    Mewton, Nathan
    Bochaton, Thomas
    [J]. ACTA PHYSIOLOGICA, 2021, 233
  • [9] IL-10 / IL-6 serum ratio as a prognosis marker of STEMI
    Leboube, S.
    Bochaton, T.
    Paccalet, A.
    Crola Da Silva, C.
    Jeantet, P.
    Amaz, C.
    De Bourguignon, C.
    Varillon, Y.
    Prieur, C.
    Tomasevic, D.
    Genot, N.
    Rioufol, G.
    Bonnefoy-Cudraz, E.
    Mewton, N.
    Ovize, M.
    [J]. EUROPEAN HEART JOURNAL, 2020, 41 : 1686 - 1686
  • [10] Association of Genetic Polymorphisms and Serum Levels of IL-6 and IL-8 with the Prognosis in Children with Neuroblastoma
    Selene Moreno-Guerrero, Silvia
    Ramirez-Pacheco, Arturo
    Maria Rocha-Ramirez, Luz
    Hernandez-Pliego, Gabriela
    Eguia-Aguilar, Pilar
    Argelia Escobar-Sanchez, Maria
    Reyes-Lopez, Alfonso
    Enrique Juarez-Villegas, Luis
    Luis Sienra-Monge, Juan Jose
    [J]. CANCERS, 2021, 13 (03) : 1 - 24
12345