Cell cycle progression without cyclin D-CDK4 and cyclin D-CDK6 complexes

被引：102
|
作者：
Kozar, K
Sicinski, P
机构：
[1] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA
[3] Med Univ Warsaw, Ctr Biostruct Res, Dept Immunol, Warsaw, Poland
来源：
CELL CYCLE | 2005年 / 4卷 / 03期
关键词：
cyclins; cyclin-dependent kinases; cell cycle; mouse knockout; hematopoiesis;
D O I：
10.4161/cc.4.3.1551
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
D-type cyclins ( cyclin D1, D2 and D3) and their associated cyclin-dependent kinases CDK4 and CDK6 were thought to represent important, perhaps essential components of the core cell cycle apparatus. However, recent analyses of mice lacking D-cyclins, or CDK4 and CDK6 reveal that these proteins are critically required for proliferation only in the selected cell types. Intriguingly, several compartments can develop in the absence of cyclin D-CDK4/6 activity, revealing that these cells can proliferate in a cyclin D-independent fashion.
引用
收藏
页码：388 / 391
页数：4
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