A Therapeutic Dendritic Cell-Based Vaccine for HIV-1 Infection

被引：97

作者：

Garcia, Felipe ^{[1
]}

Climent, Nuria ^{[1
]}

Assoumou, Lambert ^{[6
,7
]}

Gil, Cristina ^{[1
]}

Gonzalez, Nuria ^{[3
]}

Alcami, Jose ^{[3
]}

Leon, Agathe ^{[1
]}

Romeu, Joan ^{[4
]}

Dalmau, Judith ^{[5
]}

Martinez-Picado, Javier ^{[2
,5
]}

Lifson, Jeff ^{[9
]}

Autran, Brigitte ^{[8
]}

Costagliola, Dominique ^{[6
,7
]}

Clotet, Bonaventura ^{[4
,5
]}

Gatell, Josep M. ^{[1
]}

Plana, Montserrat ^{[10
]}

Gallart, Teresa ^{[1
]}

机构：

[1] Univ Barcelona, Hosp Clin Barcelona, HIV Dev Program Catalonia, Infect Dis Dept,Inst Invest Biomed August Pi & Su, E-08036 Barcelona, Spain

[2] Inst Catalana Recerca & Estudis Avancats, Barcelona, Spain

[3] Inst Salud Carlos III, AIDS Immunopathogenesis Unit, Ctr Nacl Microbiol, Madrid, Spain

[4] Hosp Badalona Germans Trias & Pujol, Lluita SIDA Fdn, Badalona, Spain

[5] IrsiCaixa Fdn, HIV Dev Program Catalonia, Badalona, Spain

[6] INSERM, U943, Paris, France

[7] Univ Paris 06, Unite Mixte Rech Sante 943, Hop La Pitie Salpetriere, Paris, France

[8] Univ Paris 06, Unite Mixte Rech Sante 945, Hop La Pitie Salpetriere, INSERM, Paris, France

[9] Sci Applicat Int Corp, AIDS & Canc Virus Program, Frederick, MD USA

[10] NCI, Frederick, MD 21701 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2011年 / 203卷 / 04期

基金：

美国国家卫生研究院;

关键词：

IMMUNIZATION; RESPONSES;

D O I：

10.1093/infdis/jiq077

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A double-blinded, controlled study of vaccination of untreated patients with chronic human immunodeficiency virus type 1 (HIV-1) infection with 3 doses of autologous monocyte-derived dendritic cells (MD-DCs) pulsed with heat inactivated autologous HIV-1 was performed. Therapeutic vaccinations were feasible, safe, and well tolerated. At week 24 after first vaccination (primary end point), a modest significant decrease in plasma viral load was observed in vaccine recipients, compared with control subjects (P = .03). In addition, the change in plasma viral load after vaccination tended to be inversely associated with the increase in HIV-specific T cell responses in vaccinated patients but tended to be directly correlated with HIV-specific T cell responses in control subjects.

引用

页码：473 / 478

页数：6

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