Amyloid deposits in the synovial tissue are usually due to a hitherto unclassified senile amyloid of the connective tissue - histologically they are characterised as foci of a congophilic substrate without cellular reaction. In this report two cases of senile transthyretin amyloidosis in patients with carpal tunnel syndrome, amyloid deposits with a surrounding granulomatous cellular reaction are described. It is assumed that this granulomatous appearance of the amyloid deposits in the synovial tissue may be an indicator of this type of amyloidosis - nevertheless, the type of amyloid should be supported by immunohistology.