The role of specialized pro-resolving mediators in maternal-fetal health

被引:18
|
作者
Elliott, E. [1 ]
Hanson, C. K. [2 ]
Anderson-Berry, A. L. [1 ]
Nordgren, T. M. [3 ,4 ]
机构
[1] Univ Nebraska Med Ctr, Pediat, 981205 Nebraska Med Ctr, Omaha, NE 68198 USA
[2] Univ Nebraska Med Ctr, Coll Allied Hlth Profess, Med Nutr Educ, 984045 Nebraska Med Ctr, Omaha, NE 68198 USA
[3] Univ Nebraska Med Ctr, Internal Med Pulm Crit Care Sleep & Allergy Div, 985910 Nebraska Med, Omaha, NE 68198 USA
[4] Univ Calif Riverside, Sch Med, Div Biomed Sci, 900 Univ Ave, Riverside, CA 92521 USA
基金
美国国家卫生研究院;
关键词
Pro-resolving lipid mediator; Pregnancy; Fetal health; Omega-3 fatty acid; Docosahexaenoic acid; Resolvins; FATTY-ACID SUPPLEMENTATION; LIPID MEDIATORS; PRORESOLVING MEDIATORS; INFLAMMATORY RESPONSE; HUMAN-MILK; RESOLUTION; PREGNANCY; PREMATURITY; EXPRESSION; LACTATION;
D O I
10.1016/j.plefa.2017.09.017
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Infants developing in a pro-inflammatory intrauterine environment have a significant risk for severe complications after birth. It has been shown that omega-3 fatty acids reduce inflammation, and also reduce early preterm births and decrease risk of infant admission to the neonatal intensive care unit. However, the mechanism for omega-3 fatty acids exerting these effects was previously unknown. Recent evidence has shown that downstream products of polyunsaturated fatty acids called specialized pro-resolving mediators may mediate inflammatory physiology, thus playing an important role in maternal-fetal health. In this review, current knowledge relating to specialized pro-resolving mediators in pregnancy, delivery, and perinatal disease states will be summarized.
引用
收藏
页码:98 / 104
页数:7
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