Susceptibility of Colistin-Resistant, Gram-Negative Bacteria to Antimicrobial Peptides and Ceragenins

被引：0
|
作者：
Hashemi, Marjan M. [1 ]
Rovig, John [1 ]
Weber, Scott [1 ]
Hilton, Brian [1 ]
Forouzan, Mehdi M. [2 ]
Savage, Paul B. [1 ]
机构：
[1] Brigham Young Univ, Dept Chem & Biochem, Provo, UT 84602 USA
[2] Brigham Young Univ, Dept Chem Engn, Provo, UT 84602 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2017年 / 61卷 / 08期
关键词：
colistin; resistant; antimicrobial peptides; ceragenin; Gram-negative bacteria; ACINETOBACTER-BAUMANNII; KLEBSIELLA-PNEUMONIAE; PSEUDOMONAS-AERUGINOSA; ESCHERICHIA-COLI; POLYMYXIN RESISTANCE; LIPOPOLYSACCHARIDE; MECHANISMS; EFFICACY; STRAINS; MCR-1;
D O I：
10.1128/AAC.00292-17
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The susceptibility of colistin-resistant clinical isolates of Klebsiella pneumoniae to ceragenins and antimicrobial peptides (AMPs) suggests that there is little to no cross-resistance between colistin and ceragenins/AMPs and that lipid A modifications are found in bacteria with modest changes in susceptibility to ceragenins and with high levels of resistance to colistin. These results suggest that there are differences in the resistance mechanisms to colistin and ceragenins/AMPs.
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页数：6
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