Circling behaviour in 6-hydroxydopamine-lesioned rats given pulsed levodopa is reduced more by lesions in the entopeduncular nucleus substantia nigra pars reticulata than in the subthalamic nucleus

被引：14
|
作者：
Honey, CR [1 ]
Shen, H [1 ]
机构：
[1] Univ British Columbia, Div Neurosurg, Vancouver, BC V6T 1Z3, Canada
来源：
NEUROSCIENCE LETTERS | 1998年 / 249卷 / 2-3期
关键词：
rodent; 6-hydroxydopamine; levodopa; subthalamic nucleus; entopeduncular nucleus; substantia nigra pars reticulata; circling behaviour; apomorphine;
D O I：
10.1016/S0304-3940(98)00431-5
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Rats unilaterally lesioned with 6-hydroxydopamine to deplete striatal dopamine received daily injections of levodopa methyl ester in combination with benserazide. Delayed lesions in the subthalamic nucleus (Group 2) or entopeduncular nucleus and substantia nigra par reticulata (Group 3) were made, unilateral to the dopamine depletion. Apomorphine-induced rotation was significantly reduced in Group 2 versus sham-operated controls (P < 0.006) and in Group 3 versus Group 2 (P < 0.03). Results suggest that enhanced apomorphine-induced rotation in this model is mediated through both the striatopallidal and striatonigral pathway. (C) 1998 Published by Elsevier Science Ireland Ltd. Ail rights reserved.
引用
收藏
页码：151 / 154
页数：4
相关论文
共 37 条
  • [1] l-dopa-induced dyskinesias in unilateral 6-hydroxydopamine-lesioned rats are not modified by excitotoxic lesion of the entopeduncular nucleus and substantia nigra pars reticulata
    Gago, Belen
    Marin, Concepcio
    Rodriguez-Oroz, Maria C.
    Obeso, Jose A.
    [J]. SYNAPSE, 2013, 67 (07) : 407 - 414
  • [2] The electrophysiological consequences of subthalamic nucleus and substantia nigra pars reticulata during high frequency stimulation in normal and unilateral 6-hydroxydopamine-lesioned rats
    Tai, CHC
    Bordaud, TT
    Gross, CC
    Bioulac, BB
    Benazzouz, AA
    [J]. MOVEMENT DISORDERS, 2002, 17 : S98 - S98
  • [3] Substantia nigra pars reticulata units in 6-hydroxydopamine-lesioned rats: responses to striatal D2 dopamine receptor stimulation and subthalamic lesions
    Tseng, KY
    Riquelme, LA
    Belforte, JE
    Pazo, JH
    Murer, MG
    [J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 2000, 12 (01) : 247 - 256
  • [4] Lesion of the pedunculopontine nucleus reverses hyperactivity of the subthalamic nucleus and substantia nigra pars reticulata in a 6-hydroxydopamine rat model
    Breit, S.
    Lessmann, L.
    Unterbrink, D.
    Popa, R. C.
    Gasser, T.
    Schulz, J. B.
    [J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 2006, 24 (08) : 2275 - 2282
  • [5] Effect of subthalamic nucleus or entopeduncular nucleus lesion on levodopa-induced neurochemical changes within the basal ganglia and on levodopa-induced motor alterations in 6-hydroxydopamine-lesioned rats
    Périer, C
    Marin, C
    Jimenez, A
    Bonastre, M
    Tolosa, E
    Hirsch, EC
    [J]. JOURNAL OF NEUROCHEMISTRY, 2003, 86 (06) : 1328 - 1337
  • [6] RESPONSES OF SUBSTANTIA-NIGRA PARS RETICULATA NEURONS TO GABA AND SKF 38393 IN 6-HYDROXYDOPAMINE-LESIONED RATS ARE DIFFERENTIALLY AFFECTED BY CONTINUOUS AND INTERMITTENT LEVODOPA ADMINISTRATION
    WEICK, BG
    ENGBER, TM
    SUSEL, Z
    CHASE, TN
    WALTERS, JR
    [J]. BRAIN RESEARCH, 1990, 523 (01) : 16 - 22
  • [7] Effects of subthalamic nucleus lesions and stimulation upon corticostriatalafferents in the 6-hydroxydopamine-lesioned rat
    Walker, R. H.
    Moore, C.
    Davies, G.
    Dirling, L.
    Kock, R. J.
    Meshul, C. K.
    [J]. MOVEMENT DISORDERS, 2012, 27 : S171 - S171
  • [8] Comparative effects of acute or chronic administration of levodopa to 6-hydroxydopamine-lesioned rats on the expression of glutamic acid decarboxylase in the neostriatum and GABAA receptors subunits in the substantia nigra, pars reticulata
    Katz, J
    Nielsen, KM
    Soghomonian, JJ
    [J]. NEUROSCIENCE, 2005, 132 (03) : 833 - 842
  • [9] (-)-Stepholidine acts as a D-1 partial agonist on firing activity of substantia nigra pars reticulata neurons in 6-hydroxydopamine-lesioned rats
    Sun, BC
    Zhang, XX
    Jin, GZ
    [J]. LIFE SCIENCES, 1996, 59 (04) : 299 - 306
  • [10] Electrical activation of the pedunculopontine tegmental nucleus modulates the neuronal activities of the subthalamic nucleus and the substantia nigra pars reticulata in anesthetized rats
    Lin, Muxin
    Wang, Ying
    Wang, Yi
    Chen, Fujun
    [J]. JOURNAL OF NEUROSCIENCE RESEARCH, 2022, 100 (11) : 2090 - 2106
1234