Leptomeningeal disease in melanoma patients: An update to treatment, challenges, and future directions

被引：37

作者：

Glitza, Isabella C. ^{[1
]}

Smalley, Keiran S. M. ^{[2
]}

Brastianos, Priscilla K. ^{[3
]}

Davies, Michael A. ^{[1
]}

McCutcheon, Ian ^{[4
]}

Liu, James K. C. ^{[5
]}

Ahmed, Kamran A. ^{[6
]}

Arrington, John A. ^{[7
]}

Evernden, Brittany R. ^{[5
]}

Smalley, Inna ^{[8
]}

Eroglu, Zeynep ^{[9
]}

Khushalani, Nikhil ^{[9
]}

Margolin, Kim ^{[10
]}

Kluger, Harriet ^{[11
]}

Atkins, Michael B. ^{[12
]}

Tawbi, Hussein ^{[1
]}

Boire, Adrienne ^{[13
]}

Forsyth, Peter ^{[5
]}

机构：

[1] UT MD Anderson Canc Ctr, Dept Melanoma Med Oncol, Houston, TX USA

[2] H Lee Moffitt Canc Ctr & Res Inst, Melanoma Res Ctr Excellence, Tampa, FL USA

[3] Massachusetts Gen Hosp, Dept Hematol Oncol, Boston, MA 02114 USA

[4] UT MD Anderson Canc Ctr, Dept Neurosurg, Houston, TX USA

[5] H Lee Moffitt Canc Ctr & Res Inst, Dept Neurooncol & Tumor Biol, Tampa, FL 33612 USA

[6] H Lee Moffitt Canc Ctr & Res Inst, Dept Radiat Oncol, Tampa, FL USA

[7] H Lee Moffitt Canc Ctr & Res Inst, Dept Radiol, Neuroradiol Sect, Tampa, FL USA

[8] H Lee Moffitt Canc Ctr & Res Inst, Dept Tumor Biol, Tampa, FL USA

[9] H Lee Moffitt Canc Ctr & Res Inst, Dept Cutaneous Oncol, Tampa, FL USA

[10] City Hope Natl Med Ctr, Dept Med Oncol & Therapeut Res, Duarte, CA 91010 USA

[11] Yale Canc Ctr, Dept Med Oncol, New Haven, CT USA

[12] Georgetown Univ, Med Ctr, Dept Med Oncol, Washington, DC 20007 USA

[13] Mem Sloan Kettering, Dept Neurooncol, New York, NY USA

来源：

PIGMENT CELL & MELANOMA RESEARCH | 2020年 / 33卷 / 04期

基金：

美国国家卫生研究院;

关键词：

intrathecal therapy; leptomeningeal carcinomatosis; leptomeningeal disease; melanoma; neoplastic meningitis; BRAIN RADIATION-THERAPY; TUMOR-INFILTRATING LYMPHOCYTES; CEREBROSPINAL-FLUID CYTOLOGY; CENTRAL-NERVOUS-SYSTEM; PHASE-II TRIAL; METASTATIC MELANOMA; INTRATHECAL INTERFERON; MALIGNANT-MELANOMA; RECOMBINANT INTERLEUKIN-2; NEOPLASTIC MENINGITIS;

D O I：

10.1111/pcmr.12861

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In February 2018, the Melanoma Research Foundation and the Moffitt Cancer Center hosted the Second Summit on Melanoma Central Nervous System Metastases in Tampa, Florida. The meeting included investigators from multiple academic centers and disciplines. A consensus summary of the progress and challenges in melanoma parenchymal brain metastases was published (Eroglu et al., Pigment Cell & Melanoma Research, 2019, 32, 458). Here, we will describe the current state of basic, translational, clinical research, and therapeutic management, for melanoma patients with leptomeningeal disease. We also outline key challenges and barriers to be overcome to make progress in this deadly disease.

引用

页码：527 / 541

页数：15

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