A simple, efficient and green procedure for the Knoevenagel condensation of aldehydes with N-methylpiperazine at room temperature under solvent-free conditions

被引：36
|
作者：
Mukhopadhyay, Chhanda [1 ]
Datta, Arup [1 ]
机构：
[1] Univ Calcutta, Dept Chem, Kolkata 700009, W Bengal, India
来源：
SYNTHETIC COMMUNICATIONS | 2008年 / 38卷 / 13期
关键词：
active methylene compounds; aldehydes; Knoevenagel condensation; N-methylpiperazine; solvent-free conditions;
D O I：
10.1080/00397910802029364
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Knoevenagel condensation of aromatic, aliphatic, and heteroaromatic aldehydes with active methylene compounds such as ethylcyanoacetate, malononitrile, and cyanoacetamide proceed very smoothly at room temperature by simply mixing the ingredients together under solvent-free conditions in the presence of N-methylpiperazine in excellent yields of the E-configured products.
引用
收藏
页码：2103 / 2112
页数：10
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