Cell microcarriers and microcapsules of stimuli-responsive polymers

被引：87

作者：

Brun-Graeppi, Amanda K. Andriola Silva ^{[1
,2
]}

Richard, Cyrille ^{[3
,4
,5
,6
]}

Bessodes, Michel ^{[3
,4
,5
,6
]}

Scherman, Daniel ^{[3
,4
,5
,6
]}

Merten, Otto-Wilhelm ^{[1
]}

机构：

[1] Genethon, F-91002 Evry, France

[2] Univ Evry Val dEssonne, Ecole Doctorale Genomes Organismes, F-91025 Evry, France

[3] CNRS, Unite Pharmacol Chim & Genet, UMR 8151, F-75270 Paris, France

[4] INSERM, U1022, F-75270 Paris, France

[5] Univ Paris 05, Fac Sci Pharmaceut & Biol, F-75270 Paris, France

[6] ENSCP Chim Paristech, F-75231 Paris, France

来源：

JOURNAL OF CONTROLLED RELEASE | 2011年 / 149卷 / 03期

关键词：

Cell microcarriers; Cell microcapsules; Stimuli-responsive polymers; Production methods; Characterization techniques; ALGINATE-BASED MICROCAPSULES; MACROPOROUS GELATIN SPHERES; LIVING CELLS; IN-VIVO; ARTICULAR CHONDROCYTES; N-ISOPROPYLACRYLAMIDE; INTESTINAL DELIVERY; ISLET ENCAPSULATION; SECRETING CELLS; PARTICLE-SIZE;

D O I：

10.1016/j.jconrel.2010.09.023

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cell microcarriers and microcapsules have presented a wide range of potential applications. This article overviews their role in biotechnology with focus on the progress accomplished using stimuli-responsive polymers. Key properties of cell microcarriers and microcapsules are identified, followed by a description of the chemistry and gel formation mechanism of some of the stimuli-responsive polymers used to design them. Production methods are introduced and characterization techniques for evaluating such microsystems are equally presented. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：209 / 224

页数：16

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