Role of 5-Hydroxytryptamine2C Receptors in Marble-Burying Behavior in Mice

被引：15

作者：

Egashira, Nobuaki ^{[1
,2
]}

Okuno, Ryoko ^{[1
]}

Shirakawa, Atsunori ^{[1
]}

Nagao, Masaki ^{[1
]}

Mishima, Kenichi ^{[1
]}

Iwasaki, Katsunori ^{[1
]}

Oishi, Ryozo ^{[2
]}

Fujiwara, Michihiro ^{[1
]}

机构：

[1] Fukuoka Univ, Fac Pharmaceut Sci, Dept Neuropharmacol, Fukuoka 8140180, Japan

[2] Kyushu Univ Hosp, Dept Pharm, Fukuoka 8128582, Japan

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2012年 / 35卷 / 03期

关键词：

marble-burying behavior; 5-hydroxytryptamine(2C) receptor; WAY161503; obsessive-compulsive disorder; fluvoxamine; paroxetine; OBSESSIVE-COMPULSIVE DISORDER; RAT; FLUVOXAMINE; INVOLVEMENT; INHIBITORS; AGONISTS; PROTEIN; CORTEX; AGENTS; SYSTEM;

D O I：

10.1248/bpb.35.376

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We examined the role of 5-hydroxytryptamine(2C) (5-HT2C) receptors in marble-burying behavior in mice. When administered alone, the selective 5-HT2C agonist WAV161503 (3 mg/kg) inhibited marble-burying behavior. Moreover, the selective 5-HT2C, antagonist SB242084 (3 mg/kg) reversed the inhibition of marble-burying behavior by 2,5-dimethoxy-4-iodoamphetamine (DOI) (1 mg/kg) or WAV161503 (3 mg/kg). Similarly, SB242084 (1 mg/kg) reversed the inhibition of marble-burying behavior by fluvoxamine (30 mg/kg) or paroxetine (3 mg/kg). These results suggest that 5-HT2C receptors play a role in marble-burying behavior in mice.

引用

页码：376 / 379

页数：4

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