Oxytocin and estrogen receptor expression in the myometrium of pregnant relaxin-deficient (Rlx-/-) mice

被引：4
|
作者：
Siebel, AL
Gehring, HM
Vodstrcil, L
Parry, LJ
机构：
[1] Univ Melbourne, Dept Zool, Parkville, Vic 3010, Australia
[2] Univ Melbourne, Howard Florey Inst Expt Physiol & Med, Parkville, Vic 3010, Australia
来源：
RELAXIN AND RELATED PEPTIDES: FOURTH INTERNATIONAL CONFERENCE | 2005年 / 1041卷
关键词：
oxytocin receptor; estrogen receptor; myometrium;
D O I：
10.1196/annals.1282.014
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Relaxin decreases oxytocin-stimulated rat myometrial contractions in vitro. This study used pregnant relaxin-deficient (Rlx(-/-)) mice to investigate the interaction between relaxin, oxytocin receptor (OTR), and estrogen receptor (ER) expression in the myometrium. Myometrial OTRs were significantly decreased on gestation day 18.5 in Rlx(-/-) mice than in Rlx(+/+) mice. An increase in ER alpha in Rlx(+/+) mice at term was correlated with a decrease in ER beta, which was not observed in Rlx(-/-) mice. Treatment of Rlx(-/-) mice with relaxin had no effect on OTR, LGR7, or ER alpha expression, but it caused a significant decrease in ER beta s.
引用
收藏
页码：104 / 109
页数：6
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