Long-term outcome of children with congenital toxoplasmosis

被引：59

作者：

Berrebi, Alain ^{[1
]}

Assouline, Corinne ^{[2
]}

Bessieres, Marie-Helene ^{[3
]}

Lathiere, Myriam ^{[2
]}

Cassaing, Sophie ^{[3
]}

Minville, Vincent ^{[2
]}

Ayoubi, Jean-Marc ^{[1
]}

机构：

[1] Hop Paule de Viguier, F-31059 Toulouse 9, France

[2] Hop Enfants, Serv Neonatol, Toulouse, France

[3] Hop Rangueil, Serv Parasitol, Toulouse, France

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2010年 / 203卷 / 06期

关键词：

chorioretinitis; intracranial lesions; pregnancy; pyrimethamine-sulfadoxine; spiramycin; Toxoplasma gondii; POLYMERASE-CHAIN-REACTION; PRENATAL TREATMENT; FOLLOW-UP; UTERO TREATMENT; AMNIOTIC-FLUID; OCULAR LESIONS; PREGNANCY; COHORT; RISK; TRANSMISSION;

D O I：

10.1016/j.ajog.2010.06.002

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

OBJECTIVE: Maternal toxoplasmosis infection acquired during pregnancy carries significant risk of fetal damage. We aimed to assess the long-term outcome of children and young adults with congenital toxoplasmosis diagnosed and treated in utero. STUDY DESIGN: This was a 20 year prospective study (1985-2005). All mothers received spiramycin, alone or associated with pyrimethamine-sulfadoxine, and underwent amniocentesis and monthly ultrasound screening. Infected children were followed every 3-6 months. RESULTS: Of 666 liveborn children (676 mothers), 112 (17%) had congenital toxoplasmosis. Among these, 107 were followed up for 12-250 months: 79 were asymptomatic (74%) and 28 had chorioretinitis (26%). Only 1 child had a serious neurological involvement. CONCLUSION: The percentage of chorioretinitis in treated children depends on length of follow-up, but this complication occurs mainly before the age of 5 years and almost always before the age of 10 years. Visual impairment was infrequently severe, and outcome appears consistently good. Long-term follow-up is recommended to monitor ocular and neurological prognosis, whatever the practical difficulties.

引用

页码：552.e1 / 552.e6

页数：6

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