Synthesis of new series of pyrazolo[4,3-d]pyrimidin-7-ones and pyrido[2,3-d]pyrimidin-4-ones for their bacterial and cyclin-dependent kinases (CDKs) inhibitory activities

被引：24
|
作者：
Geffken, Detlef [2 ]
Soliman, Raafat [1 ]
Soliman, Farid S. G. [1 ]
Abdel-Khalek, Magdi M. [1 ]
Issa, Doaa A. E. [1 ]
机构：
[1] Univ Alexandria, Fac Pharm, Dept Pharmaceut Chem, Alexandria, Egypt
[2] Univ Hamburg, Dept Pharmaceut Chem, Inst Pharm, Hamburg, Germany
来源：
MEDICINAL CHEMISTRY RESEARCH | 2011年 / 20卷 / 04期
关键词：
Pyrazole; Pyrazolo[4,3-d]pyrimidin-7-one; Pyrido[2,3-d]pyrimidin-4-one; Hydrazono-pyridazine; Antibacterial activity; ANTIBACTERIAL ACTIVITY; SILDENAFIL ANALOGS; PHENYL RING; DERIVATIVES; ACID; OLOMOUCINE; POTENT; MOIETY; CDC2;
D O I：
10.1007/s00044-010-9328-z
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two series of pyrazolo[4,3-d]pyrimidin-7-ones and pyrido[2,3-d]pyrimidin-4-ones were designed, synthesised, and evaluated for their antibacterial activities and CDKs inhibitory activities. The pyridazine derivative: 6-phenyl-5-phenylhydrazono-2,3,4,5-tetrahydropyridazine-3,4-dione (3a) revealed activity against Staphylococcus aureus as Gram-positive bacteria while compound 2-(2-Ethoxyphenyl-5-Phenylpiperazinosulfonamido)-3H-pyrido[2,3-d]pyrimidin-4-one (13c) was showing moderate antifungal activity against Candida albicans.
引用
收藏
页码：408 / 420
页数：13
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