Aim To identify predictors of burnout syndrome, such as job satisfaction and manifestations of occupational stress, in mental health workers. Method The study included a snowball sample of 174 mental health workers in Croatia. The following measurement instruments were used: Maslach Burnout Inventory, Manifestations of Occupational Stress Survey, and job Satisfaction Survey. We correlated dimensions of burnout syndrome with job satisfaction and manifestations of occupational stress dimensions. We also performed multiple regression analysis using three dimensions of burnout syndrome - emotional exhaustion, depersonalization, and personal accomplishment. Results Stepwise multiple regression analysis showed that pay and rewards satisfaction (beta = -0.37), work climate (beta = -0. 18), advancement opportunities (beta = 0.17), the degree of psychological (beta = 0.41), and physical manifestations of occupational stress (beta = 0.29) were significant predictors of emotional exhaustion (R = 0.76; F = 30.02; P < 0.001). The frequency of negative emotional and behavioral reactions toward patients and colleagues (beta = 0.48), psychological (beta = 0.27) and physical manifestations of occupational stress (beta = 0.24), and pay and rewards satisfaction (beta = 0.22) were significant predictors of depersonalization (R = 0.57; F = 13.01; P < 0.001). Satisfaction with the work climate (beta = -0.20) was a significant predictor of lower levels of personal accomplishment (R = 0.20; F = 5.06; P < 0.005). Conclusion Mental health workers exhibited a moderate degree of burnout syndrome, but there were no significant differences regarding their occupation. Generally, both dimensions of job satisfaction and manifestations of occupational stress proved to be relevant predictors of burnout syndrome.