Identification and characterisation of a cDNA encoding a 17-kDa isoform of rat myelin basic protein

被引：0

作者：

Matheus, L ^{[1
]}

Blair, GE ^{[1
]}

机构：

[1] Univ Leeds, Sch Biochem & Mol Biol, Leeds LS2 9JT, W Yorkshire, England

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 2003年 / 1630卷 / 01期

关键词：

myelin basic protein; cDNA cloning; developmental expression; brain mRNA; rat;

D O I：

10.1016/j.bbaexp.2003.08.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The myelin basic proteins (MBPs) are the major proteins of the myelin membrane. Multiple MBP mRNAs and protein isoforms are generated by alternative RNA splicing. Here we describe the isolation and characterisation of a cDNA clone encoding a 17-kDa MBP isoform from the rat (Rattus norvegicus). The isoform is a 158-amino acid protein consisting of exons 1, 3, 4, 6 and 7 of the MBP gene. RTPCR analysis of brain mRNA showed that transcripts encoding the 17-kDa isoform were expressed at higher levels early in post-natal development, up to 7 days post-partum. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：47 / 53

页数：7

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