Genetic polymorphism of serotonin transporter 5-HTTLPR: involvement in smoking behaviour

被引：16
|
作者：
Ehara Watanabe, Maria Angelica [1 ]
Vargas Nunes, Sandra Odebrechet [2 ]
Amarante, Marla Karine [1 ]
Guembarovski, Roberta Losi [1 ]
Maeda Oda, Julie Massayo [1 ]
Alves De Lima, Kalil William [1 ]
Pelegrinelli Fungaro, Maria Helena [1 ]
机构：
[1] Univ Estadual Londrina, Dept Pathol Sci, Mol Genet Lab, Univ Hosp, BR-86051990 Londrina, Brazil
[2] Univ Estadual Londrina, Dept Psychiat, Univ Hosp, BR-86051990 Londrina, Brazil
来源：
JOURNAL OF GENETICS | 2011年 / 90卷 / 01期
关键词：
serotonin; smoking; 5-HTT; genetic polymorphism; NICOTINE REPLACEMENT THERAPY; PROMOTER POLYMORPHISM; CIGARETTE-SMOKING; FOOD-INTAKE; ASSOCIATION; ALCOHOL; BINDING; REGION; SUSCEPTIBILITY; NEUROTICISM;
D O I：
10.1007/s12041-011-0037-2
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Data suggest that the serotonin (5-hydroxytryptamine, 5-HT) system is implicated in the pathogenesis of multiple neuropsychiatric disorders and may also be involved in smoking behaviour since nicotine increases brain serotonin secretion. It is known that smoking behaviour is influenced by both genetic and environmental factors. The present review examines the role of the serotonin transporter gene (5-HTT) in smoking behaviour and investigating studies that showed association of 5-HTT gene with smoking. This study discusses a polymorphism which has been investigated by many researchers, as the bi-allelic insertion/deletion polymorphism in the 5'-flanking promoter region (5-HTTLPR). This gene has received considerable attention in attempts to understand the molecular determinants of smoking. Therefore, in the present study, the relationship between genetic polymorphism of serotonin transporter in smoking behaviour is reviewed considering the interactive effect of genetic factors.
引用
收藏
页码：179 / 185
页数：7
相关论文
共 50 条
  • [1] Genetic polymorphism of serotonin transporter 5-HTTLPR: involvement in smoking behaviour
    MARIA ANGELICA EHARA WATANABE
    SANDRA ODEBRECHET VARGAS NUNES
    MARLA KARINE AMARANTE
    ROBERTA LOSI GUEMBAROVSKI
    JULIE MASSAYO MAEDA ODA
    KALIL WILLIAM ALVES DE LIMA
    MARIA HELENA PELEGRINELLI FUNGARO
    [J]. Journal of Genetics, 2011, 90 : 179 - 185
  • [2] Genetic polymorphism of serotonin transporter 5-HTTLPR: involvement in smoking behaviour (vol 90, pg 179, 2011)
    Ehara Watanabe, Maria Angelica
    Vargas Nunes, Sandra Odebrechet
    Amarante, Marla Karine
    Guembarovski, Roberta Losi
    Maeda Oda, Julie Massayo
    Alves De Lima, Kalil William
    Pelegrinelli Fungaro, Maria Helena
    [J]. JOURNAL OF GENETICS, 2011, 90 (02) : 393 - 393
  • [3] Serotonin transporter polymorphism (5-HTTLPR) in Croatian population
    Jelena Culej
    Mario Štefanović
    Ivana Ćelap
    Nora Nikolac
    Dalibor Karlović
    [J]. Molecular Biology Reports, 2015, 42 : 553 - 558
  • [4] Neuroticism is not associated with the serotonin transporter (5-HTTLPR) polymorphism
    J D Flory
    S B Manuck
    R E Ferrell
    K M Dent
    D G Peters
    M F Muldoon
    [J]. Molecular Psychiatry, 1999, 4 : 93 - 96
  • [5] Neuroticism is not associated with the serotonin transporter (5-HTTLPR) polymorphism
    Flory, JD
    Manuck, SB
    Ferrell, RE
    Dent, KM
    Peters, DG
    Muldoon, MF
    [J]. MOLECULAR PSYCHIATRY, 1999, 4 (01) : 93 - 96
  • [6] Serotonin transporter polymorphism (5-HTTLPR) in Croatian population
    Culej, Jelena
    Stefanovic, Mario
    Celap, Ivana
    Nikolac, Nora
    Karlovic, Dalibor
    [J]. MOLECULAR BIOLOGY REPORTS, 2015, 42 (02) : 553 - 558
  • [7] Psychological Response to Cancer: Role of 5-HTTLPR Genetic Polymorphism of Serotonin Transporter
    Schillani, Giulia
    Martinis, Elisabetta
    Capozzo, Maria Anna
    Era, Daniel
    Cristante, Tania
    Mustacchi, Giorgio
    Conte, Maria Anna
    De Vanna, Maurizio
    Grassi, Luigi
    Giraldi, Tullio
    [J]. ANTICANCER RESEARCH, 2010, 30 (09) : 3823 - 3826
  • [8] Dysfunctional Attitudes and the Serotonin Transporter Promoter Polymorphism (5-HTTLPR)
    Whisman, Mark A.
    Johnson, Daniel P.
    Smolen, Andrew
    [J]. BEHAVIOR THERAPY, 2011, 42 (02) : 300 - 305
  • [9] Studies of the 5-HTTLPR Serotonin Transporter Polymorphism (literature review)
    Proshina E.A.
    Bocharov A.V.
    Savostyanov A.N.
    Knyazev G.G.
    [J]. Neuroscience and Behavioral Physiology, 2022, 52 (6) : 899 - 909
  • [10] Meta-analysis of the association between a serotonin transporter 5-HTTLPR polymorphism and smoking cessation
    Choi, Hye D.
    Shin, Wan G.
    [J]. PSYCHIATRIC GENETICS, 2016, 26 (02) : 87 - 91
12345