Modafinil modulates GABA-activated currents in rat hippocampal pyramidal neurons

被引：12
|
作者：
Huang, Qing [1 ]
Zhang, Ling [2 ,3 ]
Tang, Hui [1 ]
Wang, Liecheng [2 ]
Wang, Yuanyin [1 ]
机构：
[1] Anhui Med Univ, Coll Stomatol, Hefei 230032, Peoples R China
[2] Anhui Med Univ, Dept Physiol, Hefei 230032, Peoples R China
[3] E China Normal Univ, Shanghai Inst Brain Funct Genom, Shanghai 200062, Peoples R China
来源：
BRAIN RESEARCH | 2008年 / 1208卷
基金：
中国国家自然科学基金;
关键词：
modafinil; gamma-aminobutyric acid; K-ATP channel; hippocampus;
D O I：
10.1016/j.brainres.2008.02.024
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Modafinil is a well-known psychoactive drug used to treat narcolepsy, hypoglycemia, cerebral ischemia and Parkinson's disease. Previous studies showed that ATP-sensitive potassium channels (K-ATP) play a key role in response to cerebral ischemia, hypoglycemia or metabolic inhibition. Modafinil (0.01-1 mM) dose-dependently decreased the GABA-activated currents (I-GABA). Pretreatment with the K-ATP channel blocker, glibenclamide (10 mu M), significantly reduced the decrease of I-GABA caused by modafinil. Thus, the inhibitory effect of modafinil on the I-GABA is indirect by modulating K-ATP channel activation, at least in part mediated by K-ATP channel. (C) 2008 Elsevier B.V. All rights reserved.
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页码：74 / 78
页数：5
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