Palladium N-heterocyclic carbene catalyzed regioselective C-H halogenation of 1-aryl-3-methyl-1H-pyrazol-5(4H)-ones using N-halosuccinimides (NXS)

被引：26
|
作者：
Purohit, Vishal B. [1 ]
Karad, Sharad C. [1 ]
Patel, Kirit H. [1 ]
Raval, Dipak K. [1 ]
机构：
[1] Sardar Patel Univ, Dept Chem, Vallabh Vidyanagar 388120, Gujarat, India
来源：
CATALYSIS SCIENCE & TECHNOLOGY | 2015年 / 5卷 / 06期
关键词：
SELECTIVE ORTHO-BROMINATION; CROSS-COUPLING REACTIONS; ONE-POT SYNTHESIS; DERIVATIVES BEARING; BOND FORMATION; IONIC LIQUIDS; COMPLEXES; SCAFFOLD; SP(2); EFFICIENT;
D O I：
10.1039/c5cy00137d
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
A novel palladium N-heterocyclic carbene [Pd(NHC)Cl-2] complex of vitamin B-1 was synthesized and characterized by H-1 NMR, EDX, FT-IR and UV-visible spectroscopy. The complex was used as a catalyst for regioselective ortho-C-H chlorination/bromination of 1-aryl-3-methyl-1H-pyrazol-5(4H)-ones via C-H bond activation utilizing Ag2O as the effective terminal additive. The catalyst was easy to prepare, efficient and found to be highly regioselective, affording the target products in moderate to excellent yields.
引用
收藏
页码：3113 / 3118
页数：6
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