The Utility of Metabolic Parameters on Baseline F-18 FDG PET/CT in Predicting Treatment Response and Survival in Paediatric and Adolescent Hodgkin Lymphoma
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作者:
Reed, Janet Denise
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Univ Pretoria, Dept Nucl Med, ZA-0002 Pretoria, South Africa
Steve Biko Acad Hosp, ZA-0002 Pretoria, South AfricaUniv Pretoria, Dept Nucl Med, ZA-0002 Pretoria, South Africa
Reed, Janet Denise
[1
,2
]
Masenge, Andries
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机构:
Univ Pretoria, Dept Stat, ZA-0002 Pretoria, South AfricaUniv Pretoria, Dept Nucl Med, ZA-0002 Pretoria, South Africa
Masenge, Andries
[3
]
Buchner, Ane
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机构:
Steve Biko Acad Hosp, ZA-0002 Pretoria, South Africa
Univ Pretoria, Dept Paediat Oncol, ZA-0002 Pretoria, South AfricaUniv Pretoria, Dept Nucl Med, ZA-0002 Pretoria, South Africa
Buchner, Ane
[2
,4
]
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Omar, Fareed
[2
,4
]
Reynders, David
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机构:
Steve Biko Acad Hosp, ZA-0002 Pretoria, South Africa
Univ Pretoria, Dept Paediat Oncol, ZA-0002 Pretoria, South AfricaUniv Pretoria, Dept Nucl Med, ZA-0002 Pretoria, South Africa
Reynders, David
[2
,4
]
Vorster, Mariza
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Univ Pretoria, Dept Nucl Med, ZA-0002 Pretoria, South Africa
Steve Biko Acad Hosp, ZA-0002 Pretoria, South AfricaUniv Pretoria, Dept Nucl Med, ZA-0002 Pretoria, South Africa
Vorster, Mariza
[1
,2
]
van de Wiele, Christophe
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Univ Ghent, Dept Radiol & Nucl Med, B-9000 Ghent, BelgiumUniv Pretoria, Dept Nucl Med, ZA-0002 Pretoria, South Africa
van de Wiele, Christophe
[5
]
Sathekge, Mike
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Univ Pretoria, Dept Nucl Med, ZA-0002 Pretoria, South Africa
Steve Biko Acad Hosp, ZA-0002 Pretoria, South AfricaUniv Pretoria, Dept Nucl Med, ZA-0002 Pretoria, South Africa
Sathekge, Mike
[1
,2
]
机构:
[1] Univ Pretoria, Dept Nucl Med, ZA-0002 Pretoria, South Africa
[2] Steve Biko Acad Hosp, ZA-0002 Pretoria, South Africa
[3] Univ Pretoria, Dept Stat, ZA-0002 Pretoria, South Africa
[4] Univ Pretoria, Dept Paediat Oncol, ZA-0002 Pretoria, South Africa
F-18 FDG PET;
CT (fluoro-deoxy-glucose positron emission tomography;
computed tomography);
metabolic parameters;
total metabolic tumor volume (tMTV);
total lesion glycolysis (TLG);
maximum standard uptake value (SUVmax);
paediatric oncology;
Hodgkin lymphoma (HL);
overall survival (OS);
progression-free survival (PFS);
human immunodeficiency virus (HIV);
EMISSION TOMOGRAPHY/COMPUTED TOMOGRAPHY;
PROGNOSTIC VALUE;
TUMOR BURDEN;
CHILDREN;
D O I:
10.3390/jcm10245979
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Lymphoma is the third most common paediatric cancer. Early detection of high-risk patients is necessary to anticipate those who require intensive therapy and follow-up. Current literature shows that residual tumor avidity on PET (Positron Emission Tomography) following chemotherapy corresponds with decreased survival. However, the value of metabolic parameters has not been adequately investigated. In this retrospective study, we aimed to evaluate the prognostic value of metabolic and other parameters in paediatric and adolescent Hodgkin lymphoma. We recorded tMTV (total Metabolic Tumor Volume), TLG (Total Lesion Glycolysis), and SUVmax (maximum Standard Uptake Value) on baseline PET, as well the presence of bone marrow or visceral involvement. HIV (human immunodeficiency virus) status and baseline biochemistry from clinical records were noted. All patients received stage-specific standard of care therapy. Response assessment on end-of-treatment PET was evaluated according to the Deauville criteria. We found that bone marrow involvement (p = 0.028), effusion (p < 0.001), and treatment response (p < 0.001) on baseline PET, as well as HIV status (p = 0.036) and baseline haemoglobin (p = 0.039), were significantly related to progression-free survival (PFS), whereas only effusion (p = 0.017) and treatment response (p = 0.050) were predictive of overall survival (OS). Only baseline tMTV predicted treatment response (p = 0.017). This confirms the value of F-18 FDG PET/CT (Fluoro-deoxy-glucose Positron Emission Tomography/Computed Tomography) in prognostication in paediatric and adolescent Hodgkin lymphoma; however, further studies are required to define the significance of metabolic parameters.
机构:
Southern Med Univ, NanFang PET CT Ctr, Nanfang Hosp, Guangzhou 510515, Guangdong, Peoples R ChinaSouthern Med Univ, NanFang PET CT Ctr, Nanfang Hosp, Guangzhou 510515, Guangdong, Peoples R China
Wang, Li-juan
Wu, Hu-bing
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机构:
Southern Med Univ, NanFang PET CT Ctr, Nanfang Hosp, Guangzhou 510515, Guangdong, Peoples R ChinaSouthern Med Univ, NanFang PET CT Ctr, Nanfang Hosp, Guangzhou 510515, Guangdong, Peoples R China
Wu, Hu-bing
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机构:
Wang, Meng
Han, Yan-jiang
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机构:
Southern Med Univ, NanFang PET CT Ctr, Nanfang Hosp, Guangzhou 510515, Guangdong, Peoples R ChinaSouthern Med Univ, NanFang PET CT Ctr, Nanfang Hosp, Guangzhou 510515, Guangdong, Peoples R China
Han, Yan-jiang
Li, Hong-sheng
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机构:
Southern Med Univ, NanFang PET CT Ctr, Nanfang Hosp, Guangzhou 510515, Guangdong, Peoples R ChinaSouthern Med Univ, NanFang PET CT Ctr, Nanfang Hosp, Guangzhou 510515, Guangdong, Peoples R China
Li, Hong-sheng
Zhou, Wen-lan
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机构:
Southern Med Univ, NanFang PET CT Ctr, Nanfang Hosp, Guangzhou 510515, Guangdong, Peoples R ChinaSouthern Med Univ, NanFang PET CT Ctr, Nanfang Hosp, Guangzhou 510515, Guangdong, Peoples R China
Zhou, Wen-lan
Wang, Quan-shi
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机构:
Southern Med Univ, NanFang PET CT Ctr, Nanfang Hosp, Guangzhou 510515, Guangdong, Peoples R ChinaSouthern Med Univ, NanFang PET CT Ctr, Nanfang Hosp, Guangzhou 510515, Guangdong, Peoples R China