Extracellular vesicle-orchestrated crosstalk between cancer-associated fibroblasts and tumors

被引：25
|
作者：
He, Chuanshi [1 ]
Wang, Linlin [1 ]
Li, Ling [1 ]
Zhu, Guiquan [2 ]
机构：
[1] Sichuan Canc Hosp, Dept Stomatol, Chengdu, Peoples R China
[2] Sichuan Univ, Natl Clin Res Ctr Oral Dis, State Key Lab Oral Dis, Chengdu, Sichuan, Peoples R China
来源：
TRANSLATIONAL ONCOLOGY | 2021年 / 14卷 / 12期
基金：
中国国家自然科学基金;
关键词：
Extracellular vesicle; Cancer-associated fibroblasts; Tumor microenvironment; Signal transduction; COLORECTAL-CANCER; MESENCHYMAL TRANSITION; PARACRINE INTERACTION; EXOSOMES; CELLS; MICROENVIRONMENT; PROGRESSION; MICRORNAS; INDUCE; CHEMORESISTANCE;
D O I：
10.1016/j.tranon.2021.101231
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Communication networks in the tumor microenvironment (TME) play a crucial role in tumor progression. Cancer-associated fibroblasts (CAFs) are among the most abundant stromal cells in the TME. Bidirectional signal transduction between cancer cells and CAFs within the TME is important for cancer development and treatment responsiveness. Extracellular vesicles (EVs) carrying proteins, miRNAs, and other biomolecules are secreted into the extracellular matrix (ECM), which has been demonstrated to be an important communication medium between tumors and CAFs. Tumors regulate the activation of CAFs by secreting EVs. Conversely, CAFs can also affect tumor proliferation, metastasis, and therapeutic resistance through EVs. Here, we will classify EV cargoes and discuss the role of EV-mediated interactions between CAFs and tumors, reviewing current knowledge in combination with our confirmed results.
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页数：10
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