Double robust estimator of average causal treatment effect for censored medical cost data

被引:8
|
作者
Wang, Xuan [1 ]
Beste, Lauren A. [2 ]
Maier, Marissa M. [3 ]
Zhou, Xiao-Hua [1 ,4 ]
机构
[1] Univ Washington, Dept Biostat, Seattle, WA 98195 USA
[2] Univ Washington, VA Puget Sound Hlth Care Syst, Div Gen Internal Med, VA Natl Liver Dis Database,Sch Med, Seattle, WA USA
[3] Oregon Hlth & Sci Univ, HIV Hepatitis & Publ Hlth Pathogens Program, VA Portland Hlth Care Syst,Div Infect Dis, Infect Dis Sect,Off Patient Care Serv,VHA, Portland, OR 97201 USA
[4] Seattle HSR Ctr Innovat Veteran Cr & Value Driven, Dept Vet Affairs Med Ctr, Seattle, WA USA
关键词
average causal treatment effect; censored data; double robust estimator; inverse probability weighted; lifetime medical cost data; DEPENDENT TERMINAL EVENT; PROPENSITY SCORE; LONGITUDINAL DATA; REGRESSION; TIMES; MODEL;
D O I
10.1002/sim.6876
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
In observational studies, estimation of average causal treatment effect on a patient's response should adjust for confounders that are associated with both treatment exposure and response. In addition, the response, such as medical cost, may have incomplete follow-up. In this article, a double robust estimator is proposed for average causal treatment effect for right censored medical cost data. The estimator is double robust in the sense that it remains consistent when either the model for the treatment assignment or the regression model for the response is correctly specified. Double robust estimators increase the likelihood the results will represent a valid inference. Asymptotic normality is obtained for the proposed estimator, and an estimator for the asymptotic variance is also derived. Simulation studies show good finite sample performance of the proposed estimator and a real data analysis using the proposed method is provided as illustration. Copyright (c) 2016 John Wiley & Sons, Ltd.
引用
收藏
页码:3101 / 3116
页数:16
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