Small-molecule analysis by surface-assisted laser desorption/ionization mass spectrometry

被引：37
|
作者：
Kuzema, P. A. [1 ]
机构：
[1] Natl Acad Sci Ukraine, Chuiko Inst Surface Chem, UA-03164 Kiev, Ukraine
来源：
JOURNAL OF ANALYTICAL CHEMISTRY | 2011年 / 66卷 / 13期
关键词：
mass spectrometry; MALDI; SALDI; small molecules; nanostructures; DESORPTION IONIZATION-TIME; LDI-TOF-MS; POROUS SILICON; SILVER NANOPARTICLES; GOLD NANOPARTICLES; SALDI-MS; ORGANIC-COMPOUNDS; CARBON NANOTUBES; RAPID ANALYSIS; MATRIX;
D O I：
10.1134/S1061934811130065
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
In order to meet the challenges facing modern chemistry, biology, and medicine, methods are required capable of performing rapid and reliable analysis of both individual compounds and complex mixtures at the molecular level. Matrix-assisted laser de-sorption/ionization mass spectrometry meets these requirements; however, some limitations complicate its application for the analysis of small molecules. Recently, small-molecule analysis has greatly progressed owing to development of surface-assisted laser desorption/ionization mass spectrometry involving approaches which combine the unique properties of nanostructured surface chemistry and morphology. This review examines such approaches and their specific application in small-molecule mass analysis.
引用
收藏
页码：1227 / 1242
页数：16
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